A new cationic poly(ester-anhydride): Synthesis, structure characterization, and biological properties

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標題:	A new cationic poly(ester-anhydride): Synthesis, structure characterization, and biological properties
作者:	Tsai, P.F. Hung, W.C. Chang, J.K. Shau, M.D.
貢獻者:	職業安全衛生系生物科技系
關鍵字:	Delivery-System Protein Delivery Drug Polyanhydrides Carrier Vaccines Polymers Acid
日期:	2012-07
上傳時間:	2014-03-21 16:15:14 (UTC+8)
出版者:	Maik Nauka/Interperiodica/Springer
摘要:	To improve the cytotoxicity and biocompatibility of cationic polymers used as gene carriers, new cationic poly(ester-anhydride) copolymers (Pea-PAs) bearing a quaternary ammonium group in the backbone were synthesized through a reaction between an aminoester dicarboxylic acid with a tertiary amine in the backbone and excess acetyl chloride. Their structure was characterized by nuclear magnetic resonance (NMR), Fourier transform infrared spectrometry (FTIR), and gel permeation chromatography (GPC). They degraded hydrolytically in 20 mM HEPES buffer at pH 7.4 at 37A degrees C with a half-life of more than 70 h. Their cytotoxicity was substantially lower than that of PEI. The blood clotting index (BCI) and haemolysis ratio (HR) also showed that these newly synthesized Pea-PA polymer are biopolymers with good blood compatibility.
關聯:	Polymer Science Series B, 54(7-8), 420-426
顯示於類別:	[職業安全衛生系(含防災所)] 期刊論文 [生物科技系(所)] 期刊論文

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