Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus

doi:10.1016/j.ijantimicag.2012.03.010

CNU IR > Pharmacy and Science > Dept. of Food & Drug Industry and Inspective Technology > Periodical Articles > Item 310902800/27601

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27601

Title:	Fusidic acid for the treatment of bone and joint infections caused by meticillin-resistant Staphylococcus aureus
Authors:	Wang, Jiun-Ling Tang, Hung-Jen Hsieh, Pang-Hsin Chiu, Fang-Yao Chen, Yen-Hsu Chang, Ming-Chau Huang, Ching-Tai Liu, Chang-Pan Lau, Yeu-Jun Hwang, Kao-Pin Ko, Wen-Chien Wang, Chen-Ti Liu, Cheng-Yi Liu, Chien-Lin Hsueh, Po-Ren
Contributors:	醫藥化學系
Keywords:	Fusidic Acid Meticillin-Resistant Staphylococcus Aureus (Mrsa) Bone And Joint Infection Rifampicin Combination Therapy
Date:	2012-08
Issue Date:	2014-03-21 16:14:52 (UTC+8)
Publisher:	Elsevier Science Bv
Abstract:	There is a lack of surveillance data on resistance to fusidic acid (FA) in Asia, and no reviews of FA usage for the treatment of orthopaedic infections have been conducted since the year 2000. In this study, we present a systemic literature review of FA resistance in Asia and the clinical use of FA for the treatment of bone and joint infections (BJIs). The in vitro activity of FA against meticillin-resistant Staphylococcus aureus (MRSA) isolates remains good, with low (<10%) resistance rates in most Asian countries. FA in Asia appears to be a better oral anti-MRSA agent than trimethoprim/sulfamethoxazole and clindamycin. More than 80 cases of FA use for BJI have been reported since 2000 and the recurrence or failure rate is <10%. There is much evidence supporting the use of FA in combination with other antibiotics (e. g. rifampicin) as an oral treatment following intravenous glycopeptide treatment for BJIs. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Relation:	International Journal of Antimicrobial Agents, 40(2), 103-107
Appears in Collections:	[Dept. of Food & Drug Industry and Inspective Technology] Periodical Articles

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