Flutamide,  an androgen receptor antagonist, improves heatstroke outcomes in mice

doi:10.1016/j.ejphar.2012.05.002

CNU IR > College of Sustainable Environment and Recreation > Dept. of Recreation and Health-Care Management > Periodical Articles > Item 310902800/27590

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27590

Title:	Flutamide, an androgen receptor antagonist, improves heatstroke outcomes in mice
Authors:	Lin, Chian-Yuh Hsu, Chuan-Chih Lin, Mao-Tsun Chen, Sheng-Hsien
Contributors:	休閒保健管理系
Date:	2012-08-05
Issue Date:	2014-03-21 16:14:31 (UTC+8)
Abstract:	Flutamide has been used as an adjunct for decreasing the mortality from subsequent sepsis. Heatstroke resembles septic shock in many aspects. We hypothesized that heat-induced multiple organ dysfunction syndromes and lethality could be reduced by flutamide therapy. In heatstroke groups, mice were exposed to whole body heating (41.2 degrees C, for 1 h) in a controlled-environment chamber. The heat-stressed mice were returned to normal room temperature (24 degrees C) after whole body heating. Mice still alive on day 4 of WBH treatment were considered survivors. Physiological and biochemical parameters were monitored for 2.5 h post-WBH. Heatstroke mice were subcutaneously treated with flutamide (12.5-50 mg/kg body weight in 0.05 ml) or vehicle solution (0.05 ml/kg body weight) once daily for 3 consecutive days post-WBH. We evaluated the effect of flutamide in heatstroke mice and showed that flutamide significantly (i) attenuated hypothermia, (ii) reduced the number of apoptotic cells in the hypothalamus, the spleen, the liver, and the kidney, (iii) attenuated the plasma index of toxic oxidizing radicals (e.g., nitric oxide metabolites and hydroxyl radicals), (iv) diminished the plasma index of the organ injury index (e.g., lactate dehydrogenase), (v) attenuated plasma systemic inflammation response molecules (e.g., tumor necrosis factor-a and interleukin-6), (vi) reduced the index of infiltration of polymorphonuclear neutrophils in the lung (e.g., myeloperoxidase activity), and (vii) allowed three times the fractional survival compared with vehicle. Thus, flutamide appears to be a novel agent for the treatment of mice with heatstroke or patients in the early stage of heatstroke. (C) 2012 Elsevier B.V. All rights reserved.
Relation:	European Journal of Pharmacology v.688 n.1-3 pp.62-67
Appears in Collections:	[Dept. of Recreation and Health-Care Management] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	1883	View/Open

Loading...