The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats

doi:10.3390/ijms131012224

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標題:	The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats
作者:	Chen, Ming-Jenn Chen, Tzu-Yu Cheng, Ya-Min Hsu, Yi-Chiang
貢獻者:	環境資源管理系
關鍵字:	Abdominal Adhesions Hyperbaric Oxygen (Hbo) Rats
日期:	2012-10
上傳時間:	2014-03-21 16:13:15 (UTC+8)
出版者:	Mdpi Ag, Postfach
摘要:	Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-operation difficult, with attendant risks of inadvertent enterostomy and increased operation time. The purpose of this study was to investigate the potential of hyperbaric oxygen (HBO) therapy in the prevention of abdominal adhesions in an experimental animal study. A laparotomy was performed on Wistar rats to induce the formation of adhesions on the cecum and the intra-abdominal area (1 x 2 cm). A superficial layer of the underlying muscle from the right abdominal wall was also shaved and prepared for aseptic surgery. The rats were divided into four groups according to the duration of HBO therapy; five additional groups were designated according to the conditions of HBO therapy. When the rats were evaluated according to adhesion area and grade, a statistically significant difference was observed between the control and HBO treatment groups (p < 0.005). Results from this study suggest that HBO treatment could reduce adhesion formation; and further suggest that HBO therapy may have therapeutic potential in the treatment of postoperative peritoneal adhesion.
關聯:	International Journal of Molecular Sciences, 13(10), 12224-12231
显示于类别:	[環境資源管理系(所)] 期刊論文

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