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| 標題: | Spinal blockades of class I antiarrythmic drugs with bupivacaine by isobolographic analysis in rats |
| 作者: | Chen, Yu-Wen
Chu, Chin-Chen
Chen, Yu-Chung
Leung, Yuk-Man
Wang, Jhi-Joung |
| 貢獻者: | 休閒保健管理系 |
| 關鍵字: | Flecainide
Quinidine
Mexiletine
Bupivacaine
Spinal Blockades
Isobolographic Analysis |
| 日期: | 2012-10-18 |
| 上傳時間: | 2014-03-21 16:13:03 (UTC+8) |
| 出版者: | Elsevier Ireland Ltd |
| 摘要: | Flecainide, quinidine, and mexiletine hare been shown to be sodium channel blockers and local anesthetics. The purpose of this study was to examine the interaction of the traditional local anesthetic bupivacaine with flecainide, quinidine, or mexiletine on spinal blockades. To obtain the 50% effective dose (ED50) of drugs, dose-dependent responses of spinal blockades of motor and sensory functions with intrathecal flecainide, quinidine, mexiletine, and bupivacaine in rats were constructed. Using a continuum of different fixed drug dose ratios, the interactions of bupivacaine with drugs (flecainide, quinidine, or mexiletine) were evaluated by an isobolographic analysis. Our resulting data showed that flecainide, quinidine, and mexiletine, as well as local anesthetic bilpivacaine produced dose-dependent spinal blockades in motor function and nociception. Flecainide had the most potent spinal antinociceptive effect (P < 0.01) among these three class I antiarrhythmic drugs. Co-administration of bupivacaine with flecainide, quinidine, or mexiletine displayed an additive effect on spinal blockades of motor function and nociception. We concluded that bupivacaine combined with flecainide, quinidine, or mexiletine exhibited an additive effect on spinal blockades of motor function and nociception. Using such a combination strategy to produce antinociception may potentially provide an improved therapeutic separation from myocardial toxicity occurred after spinal bupivacaine. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
| 關聯: | Neuroscience Letters v.528 n.1 pp.46-50 |
| 顯示於類別: | [休閒保健管理系(所)] 期刊論文
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