Combretastatin A-4 derivatives: synthesis and evaluation of 2,4,5-triaryl-1H-imidazoles as potential agents against H1299 (non-small cell lung cancer cell)

doi:10.1007/s11030-012-9396-8

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/27535

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27535

Title:	Combretastatin A-4 derivatives: synthesis and evaluation of 2,4,5-triaryl-1H-imidazoles as potential agents against H1299 (non-small cell lung cancer cell)
Authors:	Tseng, Chih-Hua Li, Chi-Yi Chiu, Chien-Chih Hu, Huei-Ting Han, Chein-Hwa Chen, Yeh-Long Tzeng, Cherng-Chyi
Contributors:	藥學系
Keywords:	Combretastatin A-4 (Ca-4) Triarylimidazoles H1299 Cytotoxicity Cell Cycle
Date:	2012-11
Issue Date:	2014-03-21 16:12:42 (UTC+8)
Publisher:	Springer
Abstract:	A number of 2,4,5-triaryl-1H-imidazole derivatives were synthesized and evaluated for their antiproliferative activities against the growth of five cell lines including three non-small cell lung cancers (H460, H1299, and A549), one breast cancer (MCF-7), and one normal diploid embryonic lung cell line (MRC-5). Preliminary results indicated that both 2-(5-bromofuran-2-yl)-4,5-bis{4-[3-(dimethylamino) propoxy] phenyl}-1H-imidazole (10f) and 4,5-bis{4-[3-(dimethylamino)propoxy]phenyl}-2-(5-nitrofuran-2-yl)-1H -imidazole (10g) were selectively active against the growth of H1229 with an IC50 of less than 0.1 mu M, thus were more active than topotecan (IC50 > 10.0 mu M). However, both 10f and 10g exhibited only marginal cytotoxicity against H460, A549, MCF-7, and MRC-5 requiring an IC (50) of at least 4.16 mu M. Our results also indicated that 10f induced H1299 cell cycle arrest at G0/G1 through the inactivation of p38 MAPK, JNK, ERK, as well as the expression of SIRT1 and survivin. These results suggested that 10f might have therapeutic potential against H1299 (non-small cell lung cancer cell).
Relation:	Molecular Diversity, 16(4), 697-709
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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