Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin

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题名:	Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin
作者:	Guo, Chun-Jun Knox, Benjamin P. Chiang, Yi-Ming Lo, Hsien-Chun Sanchez, James F. Lee, Kuan-Han Oakley, Berl R. Bruno, Kenneth S. Wang, Clay C.C.
贡献者:	藥學系
关键词:	Aspergillus-Terreus 3,5-Dimethylorsellinate Metabolite Austin
日期:	2012-11-16
上传时间:	2014-03-21 16:12:25 (UTC+8)
出版者:	Amer Chemical Soc
摘要:	Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
關聯:	Organic Letters, 14(22), 5684-5687
显示于类别:	[Dept. of Pharmacy] Periodical Articles

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