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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/27517

    標題: trans-Caffeic Acid Stearyl Ester from Paeonia suffruticosa Inhibits Melanin Synthesis by cAMP-Mediating Down-Regulation of alpha-Melanocyte-Stimulating Hormone-Stimulated Melanogenesis Signaling Pathway in B16 Cells
    作者: Liang, Chia-Hua
    Chou, Tzung-Han
    Tseng, Ya-Ping
    Ding, Hsiou-Yu
    貢獻者: 化妝品應用管理系
    關鍵字: Trans-Caffeic Acid Stearyl Ester
    Paeonia Suffruticosa
    日期: 2012-12
    上傳時間: 2014-03-21 16:12:07 (UTC+8)
    出版者: Pharmaceutical Soc Japan
    摘要: trans-Caffeic acid stearyl ester (TCASE) from the root cortex of Paeonia suffruticosa ANDREWS is a traditional medicinal herb that has several beneficial properties. However, the inhibitory effect of TCASE on melanogenesis has not been explored. In the cell viability assay, TCASE did not show a cytotoxic effect at a dose of 65 mu m for 48h in B16, HaCaT and Hs68 cells. TCASE considerably inhibits melanin synthesis, and reduces intracellular cyclic adenosine monophosphate (cAMP) levels, tyrosinase activity and L-3-(3,4-dihydroxyphenyl)-alanine (DOPA) oxidase activity in a concentration-dependent manner in the presence of alpha-melanocyte-stimulating hormone (alpha-MSH) in B16 cells, and the inhibition efficiency of TCASE exceeds that of ascorbic acid and arbutin. TCASE reduces melanocortin-1 receptor (MC1R), microphthalmia transcription factor (MITF), tyrosinase, tyrosinase-related protein-2 (TRP-2) and TRP-1 mRNA and protein levels in B16 cells. Based on the findings, TCASE is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITE, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyrosinase activity, DOPA oxidase activity and melanin synthesis.
    關聯: Biological & Pharmaceutical Bulletin v.35 n.12 pp.2198-2203
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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