Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27511
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    標題: Nutritional Factors in Herpes Zoster, Postherpetic Neuralgia, and Zoster Vaccination
    作者: Chen, Jen-Yin
    Chang, Chia-Yu
    Lin, Yung-Song
    Hu, Miao-Lin
    貢獻者: 老人服務事業管理系
    關鍵字: Cell-Mediated-Immunity
    Vitamin-E Therapy
    Neuropathic Pain
    Thermal Hyperalgesia
    Nerve Injury
    日期: 2012-12
    上傳時間: 2014-03-21 16:11:55 (UTC+8)
    出版者: Mary Ann Liebert Inc
    摘要: Herpes zoster (HZ) results from a reactivation of latent varicella-zoster virus (VZV). HZ and its most common complication, termed postherpetic neuralgia (PHN), often cause long-term psychological distress and physical disabilities leading to profoundly negative impacts on the quality of patients' lives. The incidence and severity of HZ and PHN increase with advanced age as a consequence of declining cell-mediated immunity. Aging has been linked to progressive senescence of the immune system and also is associated with a greater susceptibility to nutritional deficiencies. Suppressing VZV reactivation depends on intact cell-mediated immunity, which requires adequate nutrients to maintain its efficient function. Contrarily, nutritional deficiencies may lead to dysfunction of the host immune responses. Recently, micronutrient deficiencies have been shown to increase the risk of HZ and PHN and to affect the immune response to vaccinations, whereas nutritional supplements effectively reduce herpetic pain and pain in patients with PHN. As the elderly population grows, the incidence and severity of HZ and PHN are expected to increase and cause a substantial financial burden on the health care system. Thus, enhancing knowledge of the risk factors of HZ and PHN and developing better interventions to treat and prevent HZ and PHN are important to public health. This article provides an overview of the present understanding of the association among nutritional deficiencies, diminished cell-mediated immunity, and the risk of HZ and PHN, and then illustrates the potential of nutritional intervention in the prevention, vaccination, and management of HZ and PHN. (Population Health Management 2012;15:391-397)
    關聯: Population Health Management, 15(6), 391-397
    显示于类别:[高齡福祉養生管理系] 期刊論文


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