Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27508
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 18074/20272 (89%)
造訪人次 : 4161756      線上人數 : 6397
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/27508


    標題: Clinical and Prognostic Association of Transcription Factor SOX4 in Gastric Cancer
    作者: Fang, Chia-Lang
    Hseu, You-Cheng
    Lin, Yi-Feng
    Hung, Shih-Ting
    Tai, Chein
    Uen, Yih-Huei
    Lin, Kai-Yuan
    貢獻者: 生物科技系(所)
    關鍵字: Epithelial-Mesenchymal Transition
    Tumor Invasion
    Breast-Cancer
    In-Vitro
    Expression
    Carcinoma
    Genes
    Overexpression
    Metastasis
    Mice
    日期: 2012-12
    上傳時間: 2014-03-21 16:11:48 (UTC+8)
    出版者: Public Library Science
    摘要: Gastric cancer (GC) is one of the most common malignant cancers worldwide. However, little is known about the molecular process by which this disease develops and progresses. This study investigated correlations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised gastric tissues from 168 patients with GC. Paired t tests were used to analyze the differences in nuclear SOX4 expression between tumor and non-tumor tissues from each patient. Two-tailed X-2 tests were performed to determine whether the differences in nuclear SOX4 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplan-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of nuclear SOX4 expression. Overexpression of nuclear SOX4 was significantly correlated with depth of invasion (P<0.0001), nodal status (P=0.0055), distant metastasis (P=0.0195), stage (P=0.0003), and vascular invasion (P=0.0383). Patients who displayed high expression levels of nuclear SOX4 achieved a significantly poorer disease-free survival rate, compared with patients with low SOX4 expression levels (P=0.003). Univariate Cox regression analysis showed that overexpression of nuclear SOX4 was a clear prognostic marker for GC (P=0.004). Overexpression of nuclear SOX4 can be used as a marker to predict the outcome of patients with GC. Citation: Fang C-L, Hseu Y-C, Lin Y-F, Hung S-T, Tai C, et al. (2012) Clinical and Prognostic Association of Transcription Factor SOX4 in Gastric Cancer. PLoS ONE 7(12): e52804. doi:10.1371/journal.pone.0052804
    關聯: Plos One, 7(12), e52804
    顯示於類別:[生物科技系(所)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML2035檢視/開啟


    在CNU IR中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋