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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/2750

    標題: Evaluation of in Vitro Release Profiles of Developed Membrane-moderated Transdermal Delivery Systems Containing Methylephedrine HCl
    其他標題: 含鹽酸麻黃素的薄膜修飾經皮輸移系統之研發與體外釋出評估
    作者: Hung-Hong Lin
    Po-Chun Wang
    Li-Tung Hung
    Li-Ren Hsu
    貢獻者: 藥學系
    關鍵字: Methylephedrine HCl
    Membrane permeation-controlled
    Transdermal delivery system
    In vitro
    日期: 2005
    上傳時間: 2008-09-22 11:03:17 (UTC+8)
    摘要: Membrane permeation-controlled transdermal delivery devices for the controlled delivery of methylephedrine HCl were developed using calcium alginate membrane as rate-controlling membrane. To increase the solubility of methylephedrine HCl in the systems, HPMC and agar binary gel was used as drug reservoir. In vitro drug release studies were carried out using modified Franz diffusion cells. The result shows that the step of drug penetrating through the calcium alginate membrane is rate-limiting, then the rate of drug release from the patch is considered to be membrane controlled. The release kinetics of ointment and patch may be square root time dependent and the highest regression coefficient was obtained with the Higuchi model. The surface permeability of ointment was reduced by crosslinking of the membranes and enable drug continuous release over prolonged periods. Above results will be helpful to possible development of rate-controlling membrane transdermal delivery systems for the other drugs.
    關聯: 嘉南學報(科技類) 31期: p.1-8
    Appears in Collections:[嘉南學報] 31 期 (2005)
    [藥學系(所)] 期刊論文
    [醫藥化學系 ] 期刊論文

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