目前最受矚目的藥物控制釋放系統中，以高分子奈米微胞 (core-shell) 為最具潛力及前瞻性之藥物載體，而一般常見的高分子奈米微胞通常由兩性共聚物 (amphiphilic copolymer) 構成。本研究目的在於設計兩性共聚物高分子形成奈米微胞，疏水端的部分能包覆藥物形成核心，而以樹枝狀聚合物設計的親水端也能供藥物的裝載，使其具備更高的載藥量與穩定性。本研究利用生物可分解材料 poly(lactide-co-glycolide)(PLGA) 與樹枝狀聚胺基甲酸酯 (PUAD) 以脫水合成的方式，形成兩性共聚物。利用傅立葉紅外線光譜 (FT-IR) 與核磁共振光譜儀 (NMR) 確定其化學結構。並進行以下之性質研究：TEM粒徑分析、細胞毒性、藥物溶解度、藥物負載及釋放動力。綜合以上研究資料，我們發現合成之兩性共聚物高分子可以成為理想的藥物輸送系統。 Polymeric micelles is the most potential and forward-looking drug carriers among the drug delivery systems. Polymeric micelles usually consists of amphiphilic copolymer. The purpose of this study is to design amphiphilic copolymer to form polymeric micelles. Hydrophobic side of the part of the drug-coated to form the core, and then dendrimer hydrophilic end to stabilize the particles in the aqueous medium. The amphiphilic copolymer was obtained through the reaction between the PLGA and dndrimers (PUAD) via dehydration. Te chemical structure of the amphiphilic copolymer was indentified by fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR). We also studied various properties about the synthesized amphiphilic copolymer as acid-base titration to determine the particle size, critical micelle concentration, cytotoxicity, the increasement of drug solubility, drug loading and drug released kinetics. From above data, It is found that amphiphilic copolymer can be used as drug delivery system.
