Studies on the Taiwan Folk Medicine II 
Pharmacological Properties of Onychium japonicum (Thunb.) Kunze

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Title:	Studies on the Taiwan Folk Medicine II Pharmacological Properties of Onychium japonicum (Thunb.) Kunze 台灣民間藥的研究Ⅱ 日本金粉蕨的藥理作用
Authors:	Ho, Shien Tsong Yang, Meei Shieu Tsai, Shui Piao Chen, Ming Tyan Lee, Kong Ko
Contributors:	私立嘉南藥學專科學校
Date:	1981
Issue Date:	2013-11-12 13:50:19 (UTC+8)
Abstract:	Onychium japonicum (Thunb.) Kunze distributed in Taiwan, Mainland China, Himalayas, Pakistan, India, Burma, Korea, Japan, the Ryukyus, the Philippines, and Java, and always grew along hi1lsides on exposed bands in partial shade, or on shrubby hillsides. This was a general medicinal plant throughout Taiwan for alleviating gastrointestinal disorders in the folk medicinal field. In our previous study, it was carried out that the main pharmacological activity of the combined aqueous extracts from Pteris ensiformis Burm. f., Onychium japonicum (Thunb.) Kunze and Euphorbia chamaesyce L. was the inhibitory effect on intestinal smooth muscle and this activity corresponded to its diarrhea and dysentery treatment in Taiwan folk medicine. Further studies were scheduled in our laboratory to determine the pharmacological activities of these three plants individually. The preliminary results provided insight into that Onychium japonicum was pondered as a chief ingredient and subjected to further investigation. In this study, Onychium japonicum was systematically extracted and basic pharmacological examinations were programmed for each layer and traction to trace the effective components. 在民間，日本金粉蕨（Onychium japonicum）常用來治療復痛、下痢及赤痢，至今尚無實驗上的證據可循。本篇在於探討其對胃腸道、氣管等平滑肌之特性及其他肌肉之作用。今將日本金粉蕨先用沸水抽取，此水的抽出物再依序用氯仿、乙醚及醋酸乙酯進行分配。由氯仿抽出物中以分離一種具又藥理活性的新化合物，此化合物被命名為onychiol C。所有水、氯仿、乙醚、醋酸乙酯的抽出物及onychiol C均產生下列作用抑制天竺鼠廻腸的蠕動反射抑制天竺鼠廻腸對組織胺的收縮反應抑制天竺鼠氣管平滑肌對組織胺的收縮反應引起大白鼠胃平滑肌對血清毒素（serotonin）的反應。在這些物質中以onychiol C的作用最強，故此新化合物被認為是日本金粉蕨的有效成分之一。
Relation:	嘉南學報 7, (轉載論文) 台灣藥學雜誌第三十二卷第一期(1980)
Appears in Collections:	[Chna Nan Annual Bulletin] Vol.7 (1981)

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