Characterization of quaternized chitosan-stabilized iron oxide nanoparticles as a novel potential magnetic resonance imaging contrast agent for cell tracking

doi:10.1002/pi.3059

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/27069

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题名:	Characterization of quaternized chitosan-stabilized iron oxide nanoparticles as a novel potential magnetic resonance imaging contrast agent for cell tracking
作者:	Shen, Chia-Rui Wu, Shu-Ting Tsai, Zei-Tsan Wang, Jiun-Jie Yen, Tzu-Chen Tsai, Jin-Sheng Shihe, Mei-Fen Liu, Chao-Lin
贡献者:	藥學系
关键词:	cell tracking chitosan N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC) magnetic resonance imaging (MRI) superparamagnetic iron oxide (SPIO)
日期:	2011-06
上传时间:	2013-10-25 15:33:45 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	Polymer-stabilized iron oxide nanoparticles could be used as contrast agents in magnetic resonance imaging (MRI) due to their unique superparamagnetism. Here we demonstrate a quaternized chitosan, i.e. N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC), encapsulating superparamagnetic iron oxide (SPIO), with very low toxicity and less effect on cell growth. HTCC has quaternary amino groups introduced into the chitosan chain, and such modification of chitosan should render it soluble in water. Most importantly, the HTCC–SPIO thus prepared has the ability to accelerate the MRI relaxation processes of surrounding water protons, resulting in enhanced MRI contrast (R2: y = 0.1076x − 0.0092; R1: y = 0.008x − 0.0005). The iron content quantified by Prussian blue staining and MRI revealed a positive correlation between Prussian blue positive cells and the change of MRI signal intensity. Also, transmission electron microscopy and element mapping confirmed intracellular metal-like spots as internalized iron oxide. Such findings support the use of these quaternized chitosan-stabilized iron oxide nanoparticles as a potential MRI contrast agent for cell tracking. Copyright © 2011 Society of Chemical Industry
關聯:	Polymer International, 60(6,S1), pp.945-950
显示于类别:	[Dept. of Pharmacy] Periodical Articles

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