Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/27069
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18034/20233 (89%)
Visitors : 23362448      Online Users : 604
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/27069


    Title: Characterization of quaternized chitosan-stabilized iron oxide nanoparticles as a novel potential magnetic resonance imaging contrast agent for cell tracking
    Authors: Shen, Chia-Rui
    Wu, Shu-Ting
    Tsai, Zei-Tsan
    Wang, Jiun-Jie
    Yen, Tzu-Chen
    Tsai, Jin-Sheng
    Shihe, Mei-Fen
    Liu, Chao-Lin
    Contributors: 藥學系
    Keywords: cell tracking
    chitosan
    N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC)
    magnetic resonance imaging (MRI)
    superparamagnetic iron oxide (SPIO)
    Date: 2011-06
    Issue Date: 2013-10-25 15:33:45 (UTC+8)
    Publisher: Wiley-Blackwell
    Abstract: Polymer-stabilized iron oxide nanoparticles could be used as contrast agents in magnetic resonance imaging (MRI) due to their unique superparamagnetism. Here we demonstrate a quaternized chitosan, i.e. N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride (HTCC), encapsulating superparamagnetic iron oxide (SPIO), with very low toxicity and less effect on cell growth. HTCC has quaternary amino groups introduced into the chitosan chain, and such modification of chitosan should render it soluble in water. Most importantly, the HTCC–SPIO thus prepared has the ability to accelerate the MRI relaxation processes of surrounding water protons, resulting in enhanced MRI contrast (R2: y = 0.1076x − 0.0092; R1: y = 0.008x − 0.0005). The iron content quantified by Prussian blue staining and MRI revealed a positive correlation between Prussian blue positive cells and the change of MRI signal intensity. Also, transmission electron microscopy and element mapping confirmed intracellular metal-like spots as internalized iron oxide. Such findings support the use of these quaternized chitosan-stabilized iron oxide nanoparticles as a potential MRI contrast agent for cell tracking. Copyright © 2011 Society of Chemical Industry
    Relation: Polymer International, 60(6,S1), pp.945-950
    Appears in Collections:[Dept. of Pharmacy] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    index.html0KbHTML1960View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback