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    Title: The Performance of Risk Scores and Hemoglobin A1c to Find Undiagnosed Diabetes with Isolated Postload Hyperglycemia
    Authors: Li1, Hung-Yuan
    Lin, Mao-Shin
    Shyang-Rong ShihChiao8), Jung-Nan Wei8)
    Hua, Cyue-Huei
    Liu, Yu-Lai
    Chuang, Lee-Ming
    Sung, Fung-Chang
    Chen, Ming-Fong
    Lee, Jin-Chuan
    Contributors: 職業安全衛生系
    Keywords: Isolated postload hyperglycemia
    Risk score
    Impaired fasting glucose
    Date: 2011-06
    Issue Date: 2013-10-23 11:55:50 (UTC+8)
    Publisher: Japan Soc Biosci Biotechn Agrochem
    Abstract: The aim of this study is to develop strategies to screen diabetic subjects with isolated postload hyperglycemia (IPH) in Chinese population. We included 1175 adult subjects who did not report diabetes were included. Diabetes was diagnosed by oral glucose tolerance tests. IPH was defined as fasting plasma glucose (FPG)<7 mmol/L and 2-hour post-load plasma glucose (2hPG) greater than 11.1 mmol/L. Using FPG criteria, only 59.8% of diabetic subjects were not identified, showing a poor agreement between FPG and 2hPG criteria (kappa 0.294). Age, FPG, total cholesterol, triglycerides, blood pressure, body mass index, HbA1c and medication for hypertension were associated factors for IPH. Four scores were constructed using all these factors, age and blood test results, age and HbA1 c, and data from non-invasive examinations, respectively. The area under the ROC curve were 0.9296(95%CI 0.8948-0.9643), 0.9111(95%CI 0.8713-0.9508), 0.8902(95%CI 0.8341-0.9646), 0.8924(95%CI 0.7835-0.8753), and 0.8654(95%CI 0.7963-0.9345) for score 1, 2, 3, 4, and HbA1 c, respectively. The sensitivity of all four risk scores to detect IPH was better than that of impaired fasting glucose (IFG). The sensitivity and specificity of HbA1c at cutoff 6.2% for detecting IPH was also better than that of IFG. In conclusion, the risk scores and HbA1c are useful to identify subjects with undiagnosed IPH, with better performance than IFG.
    Relation: Endocrine Journal , 58(6), pp.441-448
    Appears in Collections:[Dept. of Occupational Safety] Periodical Articles

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