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    Title: Macrophage Mediated Anti-Proliferation Effects of Anthodia camphorata Non-Polysaccharide Based Extracts on Human Hepatoma Cells
    Authors: CHANG, Chia-Yu
    CHENG, Tain-Junn
    CHANG, Fang-Rong
    WANG, Hsien-Yi
    KAN, Wei-Chih
    Shun-Lai, LI
    HUANG, Li-Hsueh
    CHEN, Yu-Chun
    TSAI, Wan-Chen
    HUANG, Chia-Hsin
    CHENG, Chia-Hui
    LEE, Guo-Yang
    SHYUE, Shiang-Wei
    CHEN, Yi-Peng
    LIN, Kao-Chang
    CHUU, Jiunn-Jye
    Contributors: 職業安全衛生系
    Keywords: Antrodia camphorata
    Date: 2011-04
    Issue Date: 2013-10-23 11:55:45 (UTC+8)
    Publisher: Japan Soc Biosci Biotechn Agrochem
    Abstract: It has been reported that medicinal mushrooms might induce different types of immune responses. Anthodia camphorata (A. camphorata) has attracted much attention for its therapeutic effects in treating hepatoma. We tested this anti-tumor effects using immunomodulation of macrophages and extracts of A. camphorata. We evaluated the anti-proliferation effects of various extracts of A. camphorata from fruiting bodies (AC-FB), mycelium of solid-state cultures (AC-SS), liquid-state cultures (AC-LS) and polyaccharide extracts from liquid-state cultures (AC-PS), and extracts of A. camphorata stimulated RAW 264.7 macrophage cell-conditioned mediums (MC-CMs). We measured cell proliferation and, did migration assays by cell cycle analysis and by observing apoptosis-related proteins (AKT, PARP-1, and NF-kappa B) and the mRNA expression of cytokines (TNF-alpha and IL-1 beta) of macrophages in human hepatoma cell lines. Our results revealed that two of the extracts (AC-FB and AC-SS) had better anti-proliferation effects, implying an immunomodulatory role the macrophages might play. This outcome is consistent with findings that AC-FB and AC-SS increase mRNA expression of TNF-a and the corresponding expression of apoptosis-related proteins on activation of MC-CMs, while A. camphorata polysaccharides induce macrophage-derived anti-tumor activities in human hepatoma cells via IL-1 beta and Akt activation. These results indicate that anti-tumor effects exerted by modulation of macrophage activation of A. camphorate may be influenced by the other constituents which (contained little or no polysaccharide) of A. camphorata.
    Relation: Bioscience, Biotechnology, and Biochemistry , 75(4), pp.624-632
    Appears in Collections:[Dept. of Occupational Safety] Periodical Articles

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