Transformation of cinnamic acid from trans- to cis-form raise a notable bactericiadl and synergistic activity against multiple-drugs resistant Mycobacterium tuberculosis

doi:10.1016/j.ejps.2011.04.012

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標題:	Transformation of cinnamic acid from trans- to cis-form raise a notable bactericiadl and synergistic activity against multiple-drugs resistant Mycobacterium tuberculosis
作者:	Chen, Yen-Ling Huang, Shao-Tsung Sun, Fang-Ming Chiang, Yu-Ling Chiang, Chia-Jung Tsai, Chiung-Man Weng, Chia-Jui
貢獻者:	保健營養系(所)
關鍵字:	cis-cinnamic acid
日期:	2011-06
上傳時間:	2013-06-26 11:37:04 (UTC+8)
摘要:	Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis. The long course of treatments on TB with a combination of antibiotics leads unfavorable side effects and poor patient compliance which contributes to sustaining multiple-drug resistant tuberculosis (MDR-TB). Therefore, the development of a new effective drug or synergist to reduce the prevalence of MDR-TB is urgent to date. Cinnamic acid (CA) is a natural occurring phenolic compound with anti-microbial activity. Both trans- and cis-isoforms of CA exist in planta, and cis-cinnamic acid (c-CA) can be transformed from trans-cinnamic acid (t-CA) under sunlight. Due to the unavailability of c-CA, the literature regarding the biological functions of c-CA is still limited. We had previously developed a practicable method for the transformation of c-CA from t-CA and the isolation of c-CA. Using the techniques, sufficient c-CA was obtained to evaluate its antituberculosis activity against a MDR M. tuberculosis strain. Moreover, the synergistic effects of c-CA and t-CA with two first-line anti-TB antibiotics, isoniazid (INH) and rifampicin (RIF), were also determined. Although both of c-CA and t-CA decreased the viability of MDR-TB bacilli in a dose-dependent manner, the antituberculosis activity of c-CA was approximately 120-fold of t-CA. Furthermore, the c-CA exhibited higher synergistic effect with INH or RIF against tuberculosis than t-CA. The micrographs of scanning electron microscope (SEM) display that c-CA caused an injury on the out-layer of MDR-TB bacilli. The c-CA might be a potential anti-mycobacterial or synergistic agent that can be developed to against tuberculosis.
關聯:	European Journal of Pharmaceutical Sciences 43(3), pp.188-194
顯示於類別:	[保健營養系(所) ] 期刊論文

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