A comparative study on the effective ness of cis- and trans-forms of cinnamic acid treatment for inhibiting invasive activity for human lung adenocarcinoma cells

doi:10.1016/j.ejps.2011.08.006

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標題:	A comparative study on the effective ness of cis- and trans-forms of cinnamic acid treatment for inhibiting invasive activity for human lung adenocarcinoma cells
作者:	Yen, Gow-Chin Chen, Yen-Ling Sun, Fang-Ming Chiang, Yu-Ling Lu, Shiau-Huei Weng, Chia-Jui
貢獻者:	保健營養系(所)
關鍵字:	Cinnamic acid
日期:	2011-10
上傳時間:	2013-06-26 11:36:53 (UTC+8)
摘要:	Lung cancer is the major cause of tumor-related death, and approximately 70% of lung cancer patients die from metastasis. Evidence that phenolic compounds may have a potential inhibitory effect on cancer invasion and metastasis is increasingly being reported in the scientific literature. Cinnamic acid is a member of phenolics which having several isoforms in nature. The trans-cinnamic acid (t-CA) has been investigated extensively for its potential pharmacological effects whereas the study of cis-cinnamic acid (c-CA) is limited because pure c-CA was hard to obtain. We had developed a practicable method previously to transform and obtain pure c-CA, and the pure compound was used to evaluate the anti-invasive effect on human adenocarcinoma A549 cells. The A549 cells were treated with 0–200 μM of c-CA and t-CA in the presence of 200 nM phorbol-12-myristate-13-acetate (PMA) at 37 °C for 24 h, and matrix metalloproteinase (MMP)-2, MMP-9, adhesive, migratory, and invasive activities of the cells were determined. The results showed that the treatment of c-CA and t-CA dose-dependently reduced the PMA-induced MMP-2 and -9 activities but without significant effect on the adhesive activity of cells. The PMA-induced motility was suppressed in a dose-dependent manner by a 24-h treatment with c-CA and t-CA. The invasive ability was significantly (p < 0.05) reduced to 68% and 65%, respectively, relative to PMA treatment alone after treatment of PMA-treated A549 cells with either 50 μM c-CA or 100 μM t-CA for 24 h. The results suggest that both of the c-CA and t-CA are inhibitors for invasion of A549 cells and the activity of c-CA seems to be higher than t-CA.
關聯:	European Journal of Pharmuceutical Sciences 44(3), pp.281-287
显示于类别:	[保健營養系(所) ] 期刊論文

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