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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/26718


    標題: Predictors of Longterm Mortality in Patients with and without Systemic Lupus Erythematosus on Maintenance Dialysis: A Comparative Study
    作者: CHEN, HUNG-AN
    WANG, JHI-JOUNG
    CHOU, CHUNG-TEI
    CHIEN, CHIH-CHIANG
    CHU, CHIN-CHEN
    SHEU, MING-JEN
    LIN, YEONG-JANG
    CHEN, PEI-CHIH
    CHEN, CHUN-HSIUNG
    貢獻者: 休閒保健管理系
    關鍵字: DIALYSIS
    MORTALITY
    OUTCOMES
    SYSTEMIC LUPUS ERYTHEMATOSUS
    日期: 2011-11
    上傳時間: 2013-06-21 16:52:31 (UTC+8)
    摘要: Objective. To compare the prognosis of patients with and without systemic lupus erythematosus (SLE) on dialysis and to determine the factors that affect survival after dialysis.

    Methods. We used the Taiwan National Health Insurance Research Database (NHRI-NHIRD-99182) and collected data on patients who started maintenance dialysis between 2001 and 2003. Patients were followed from the initiation of dialysis until death, discontinuation of dialysis, or the end of 2008. We did a Kaplan-Meier analysis of the cohort and used multivariate Cox regression analysis to identify significant predictors of survival.

    Results. Of the 22,394 dialysis patients studied, 303 (1.35%) had SLE. Hypertension and diabetes were the 2 most common comorbidities associated with dialysis for patients with and without SLE. After adjusting for age, sex, dialysis modality, and comorbidities, we found no significant survival difference between the 2 patient groups after 8 years of followup. Multivariate analysis showed that increased mortality in the patient group without SLE (p < 0.05) was associated with older age (≥ 45 years), male sex, initial choice of hemodialysis, diabetes mellitus, heart failure, coronary artery disease, cerebrovascular disease, and malignancy. In the patient group with SLE, independent predictors of mortality (p < 0.05) were older age (≥ 65 years), male sex, and diabetes mellitus.

    Conclusion. The longterm survival outcome was similar between patients with and without SLE who were on dialysis. The factors affecting patient mortality were not identical in these 2 groups.
    關聯: Journal of rheumatology 38(11), pp. 2390-2394
    Appears in Collections:[休閒保健管理系(所)] 期刊論文

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