Clonidine as adjuvant for oxybuprocaine, bupivacaine or dextrorphan has a significant peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats

doi:10.1016/j.neulet.2011.04.021

Chia Nan University of Pharmacy & Science Institutional Repository > 環境永續暨休閒學院 > 休閒保健管理系(所) > 期刊論文 > Item 310902800/26713

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標題:	Clonidine as adjuvant for oxybuprocaine, bupivacaine or dextrorphan has a significant peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats
作者:	Chen, Yu-Wen Chu, Chin-Chen Chen, Yu-Chung Hung, Ching-Hsia Hsueh, Meng-I Wang, Jhi-Joung
貢獻者:	休閒保健管理系
關鍵字:	Clonidine Oxybuprocaine Bupivacaine Dextrorphan Infiltrative cutaneous analgesia
日期:	2011-06
上傳時間:	2013-06-21 16:52:23 (UTC+8)
出版者:	Elsevier
摘要:	The aim of the study was to evaluate co-administration of clonidine with oxybuprocaine (ester type), bupivacaine (amide type) or dextrorphan (non-ester or non-amide type) and to see whether it could have a peripheral action in enhancing local anesthesia on infiltrative cutaneous analgesia in rats. Cutaneous analgesia was evaluated by a block of the cutaneous trunci muscle reflex (CTMR) in response to local dorsal cutaneous noxious pinprick in rats. The analgesic effect of the addition of clonidine with oxybuprocaine, bupivacaine or dextrorphan by subcutaneous injection was evaluated. On an ED50 basis, the rank of drug potency was oxybuprocaine > bupivacaine > dextrorphan (P < 0.01). Mixtures of clonidine (0.12 μmol) with oxybuprocaine, bupivacaine or dextrorphan (ED50 or ED95) extended the duration of action and increased the potency on infiltrative cutaneous analgesia. Among these drugs, the addition of clonidine to bupivacaine (amide type) elicits the most effective cutaneous analgesia. Clonidine at the dose of 0.12 and 0.24 μmol did not produce cutaneous analgesia. Oxybuprocaine showed more potent cutaneous analgesia than bupivacaine or dextrorphan in rats. Co-administration of oxybuprocaine, bupivacaine or dextrorphan with clonidine increased the potency and duration on infiltrative cutaneous analgesia. The addition of clonidine to bupivacaine (amide type) elicits more effective cutaneous analgesia than oxybuprocaine (ester type) or dextrorphan (non-ester or non-amide type).
關聯:	neuroscience letters 496(3), pp. 186-190
显示于类别:	[休閒保健管理系(所)] 期刊論文

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