Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters

doi:10.1016/j.foodchem.2011.01.116

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Title:	Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters
Authors:	Hsu, Chin-Lin Chang, Yuan-Yen Chiu, Chih-Hsien Yang, Kuo-Tai Wang, Yu Fu, Shih-Guei Chen, Yi-Chen
Contributors:	生活應用與保健系
Keywords:	Deep seawater Cardiovascular protection LDL receptor CYP7A1 Hamster Serum lipids Serum lipid peroxidation
Date:	2011-08
Issue Date:	2013-06-20 15:53:06 (UTC+8)
Publisher:	Elsevier
Abstract:	Cardiovascular protection of deep-seawater (DSW) drinking water was assessed using high-fat/cholesterol-fed hamsters in this study. All hamsters were fed a high-fat/cholesterol diet (12% fat/0.2% cholesterol), and drinking solutions were normal distiled water (NDW, hardness: 2.48 ppm), DSW300 (hardness: 324.5 ppm), DSW900 (hardness: 858.5 ppm), and DSW1500 (hardness: 1569.0 ppm), respectively. After a 6-week feeding period, body weight, heart rates, and blood pressures of hamsters were not influenced by DSW drinking waters. Serum total cholesterol (TC), triacylglycerol (TAG), atherogenic index, and malondialdehyde (MDA) levels were decreased (p < 0.05) in the DSW-drinking-water groups, as compared to those in the NDW group. Additionally, increased (p < 0.05) serum Trolox equivalent antioxidant capacity (TEAC), and faecal TC, TAG, and bile acid outputs were measured in the DSW-drinking-water groups. Hepatic low-density-lipoprotein receptor (LDL receptor) and cholesterol-7α-hydroxylase (CYP7A1) gene expressions were upregulated (p < 0.05) by DSW drinking waters. These results demonstrate that DSW drinking water benefits the attenuation of high-fat/cholesterol-diet-induced cardiovascular disorders in hamsters.
Relation:	Food Chemistry 127(3), pp. 1146-1152
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles

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