Protective effects of three smoke flavouring phenols on oxidative damage and nitric oxide production

doi:10.1016/j.foodchem.2010.12.049

CNU IR > College of Smart Living > Dept. of Life and Health Science > Periodical Articles > Item 310902800/26704

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/26704

Title:	Protective effects of three smoke flavouring phenols on oxidative damage and nitric oxide production
Authors:	Huang, Ming-Hsing Chang, Lee-Wen Sung, Wen-Chieh Vong, Wen-Jong Wang, Bor-Sen
Contributors:	生活應用與保健系化粧品應用與管理系
Keywords:	Methoxyphenol Oxidative damage Glutathione Nitric oxide Lipopolysaccharide
Date:	2011-06
Issue Date:	2013-06-20 15:52:59 (UTC+8)
Publisher:	Elsevier
Abstract:	In this study, the effects of three smoke flavouring phenols, including 4-methoxyphenol (4-MP), 4-ethyl-2-methoxyphenol (EMP), and 4-propenyl-2-methoxyphenol (isoeugenol), on oxidative damage and nitric oxide production, were examined. In the range 5–20 μM, EMP displayed the highest inhibitory effects on radical production and biomolecule oxidation in the acellular systems of the three smoke flavouring phenols. In addition, 4-MP, EMP and isoeugenol, in the range 5–20 μM, protected liver cells against tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity, correlating with protection against intracellular glutathione depletion. Meanwhile, the inhibitory effects of the three smoke flavouring phenols on nitric oxide (NO) generation, in lipopolysaccharide (LPS)-stimulated macrophages, increased with increasing concentrations. The decrease in NO production was attributed to the reduced inducible nitric oxide synthase (iNOS) expression in macrophages. These data suggested that the three smoke flavouring phenols, particularly EMP, show biological activities that contribute to antioxidation as well as anti-inflammation.
Relation:	Food Chemistry 126(4), pp. 1655-1661
Appears in Collections:	[Dept. of Life and Health Science] Periodical Articles [Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	2154	View/Open

Loading...