Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo

doi:10.1016/j.jep.2010.11.005

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/26684

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標題:	Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo
作者:	Huang, Ming-Hsing Huang, Shyh-Shyun Wang, Bor-Sen Wu, Chieh-Hsi Sheu, Ming-Jyh Hou, Wen-Chi Lin, Shiang-Shiou Huang, Guan-Jhong
貢獻者:	化粧品應用與管理系生活應用與保健系
關鍵字:	Cardiospermum halicacabum Chinese medicine Antioxidant Anti-inflammation NO TNF-α
日期:	2011-01
上傳時間:	2013-06-03 15:53:06 (UTC+8)
出版者:	Elsevier Elsevier Elsevier
摘要:	Aims of the study Cardiospermum halicacabum (CH) has been used in Chinese medicine for a long time. However, its fingerprint chromatogram, antioxidant, anti-inflammatory effects and mechanism are still needed to be explored. Therefore, the aims of this study investigated the antioxidant and anti-inflammatory effects of CH extracts and its reference compounds ex vivo and in vivo. Materials and methods In HPLC analysis, the fingerprint chromatogram of ethanolic extract of CH (ECH) was established. The effects of ACH (aqueous extract of CH) and ECH extracts were assessed for the antioxidant and LPS-induced NO production in RAW264.7 cells. In vivo anti-inflammatory activities of ECH were evaluated in mouse paw edema induced by λ-carrageenan (Carr). We investigate the anti-inflammatory mechanism of ECH via studies of the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver and the levels of malondialdehyde (MDA) and nitrite oxide (NO) in the edema paw. Serum NO and TNF-α were also measured. Results ECH had better antioxidant activity than that of ACH. In the anti-inflammatory test, ECH inhibited the development of paw edema induced by Carr and increased the activities of CAT, SOD and GPx in the liver tissue. ECH also decreased the level of NO in edematous paw tissue and in serum level, and diminished the level of serum TNF-α at the fifth hour after Carr injection. Conclusions ECH exerts anti-inflammatory effects by suppressing TNF-α and NO. The anti-inflammatory mechanism of ECH might be related to the decrement of the level of MDA in the edema paw via increasing the activities of CAT, SOD and GPx in the liver. The results showed that ECH might serve as a natural antioxidant and anti-inflammatory agent.
關聯:	Journal of Ethnopharmacology 133(2), pp. 743-750
显示于类别:	[化妝品應用與管理系(所)] 期刊論文 [生活保健科技系] 期刊論文

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