Paraminabeolides A−F, Cytotoxic and Anti-inflammatory Marine Withanolides from the Soft Coral Paraminabea acronocephala

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Title:	Paraminabeolides A−F, Cytotoxic and Anti-inflammatory Marine Withanolides from the Soft Coral Paraminabea acronocephala
Authors:	Chao, Chih-Hua Chou, Kuei-Ju Wen, Zhi-Hong Wang, Guey-Horng Wu, Yang-Chang Dai, Chang-Feng Sheu, Jyh-Horng
Contributors:	化粧品應用與管理系
Date:	2011-01
Issue Date:	2013-06-03 15:52:54 (UTC+8)
Abstract:	Six new withanolides, paraminabeolides A−F (1−6), along with five known compounds, minabeolides-1, -2, -4, -5, and -8 (7−11), were isolated from a Formosan soft coral, Paraminabea acronocephala. The structures of these compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The absolute configuration of 4 was determined by the application of Mosher’s method. Compounds 1 and 7 were cytotoxic toward Hep G2 cancer cells. Compounds 1−4 and 7−10 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein. Compounds 7−10 also could effectively reduce the expression of COX-2 protein.
Relation:	Journal of Nature Products 74(5), pp. 1132-1141
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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