Murine tyrosinase Inhibitors from Cynanchum bungei andevaluation of in vitro and in vivo depigmenting activity

doi:10.1111/j.1600-0625.2011.01302.x

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/26668

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標題:	Murine tyrosinase Inhibitors from Cynanchum bungei andevaluation of in vitro and in vivo depigmenting activity
作者:	Ding, Hsiou-Yu Chang, Te-Sheng Shen, Hung-Chang Tai, Sorgan Shou-Ku
貢獻者:	化粧品科技研究所
關鍵字:	acetophenone Cynanchum bungei melanogenesis tyrosinase inhibitor zebrafish
日期:	2011-09
上傳時間:	2013-06-03 15:52:50 (UTC+8)
出版者:	Wiley
摘要:	Two natural acetophenone derivatives, 2,5-dihydroxyacetophenone (2,5-DHAP) and 2,6-DHAP, were purified from Cynanchum bungei and identified as murine tyrosinase inhibitors. Investigation into 2,5-DHAP showed it to be an uncompetitive inhibitor of murine tyrosinase (KI 0.28 mm). 2,5-DHAP strongly inhibited both melanogenesis and cellular tyrosinase activity in vitro in 3-isobutyl-1-methylxanthin-stimulated B16 mouse melanoma cells or in vivo in zebrafish and mouse models, but showed no cytotoxicity at the concentrations used. In B16 cells, 2,5-DHAP inhibition was dose-dependent and was fourfold greater than that of arbutin. 2,5-DHAP had no effect on the expression of tyrosinase protein or mRNA, as confirmed by Western blotting and quantitative real-time reverse transcription polymerase chain reaction, respectively. A 2% gel preparation of 2,5-DHAP applied to the skin of mice significantly increased the average skin-whitening index (L value), indicating its potential use as a treatment for skin hyperpigmentation in humans.
關聯:	Experimental Dermatology 20(9), pp. 720-724
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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