Melanogenesis inhibition by a crude extract of Magnolia officinalis

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標題:	Melanogenesis inhibition by a crude extract of Magnolia officinalis
作者:	Ding, Hsiou-Yu Chang, Te-Sheng Chiang, Chien-Min Li, Sin-Yi Tseng, Deng-Yu
貢獻者:	化粧品科技研究所生物科技系(所) 1996-0875
關鍵字:	Magnolia officinalis melanogenesis tyrosinase melanin inhibition
日期:	2011-01
上傳時間:	2013-06-03 15:52:49 (UTC+8)
出版者:	Academic Journals
摘要:	In the present study, we investigated the inhibitory effect of a crude extract from Magnolia officinalis (MOE) on melanogenesis in both mouse B16 melanoma cells and zebrafish. Our results showed that MOE inhibited melanogenesis in either a-melanocyte stimulating hormone (a-MSH)- or 3-isobutyl-1-methylxanthin (IBMX)-stimulated B16 cells in a dose-dependent manner with an IC50 value of 9.3 µg/ml. In addition, MOE also inhibited cellular tyrosinase activity with an IC50 value of 13.4 µg/ml while no inhibitory activity was found by MOE against cell-free tyrosinase activity. Moreover, western blotting and real time reverse-transcription polymerase chain reaction (qRT-PCR) analyses, respectively confirmed that MOE downregulated levels of tyrosinase protein but not that of its mRNA in a-MSH-stimulated B16 cells. These results demonstrated that MOE inhibits melanogenesis of B16 cells by a pre-translational regulation on tyrosinase gene expression. On the other hand, when using zebrafish as a depigmenting assay system, MOE could inhibit both melanogenesis and tyrosinase activity in the in vivo model. From the present study, MOE was proven to be a good candidate as a skin-whitening agent for treatment of skin hyperpigmentation.
關聯:	Journal of Medicinal Plants Research 5(2), pp. 237-244
显示于类别:	[化妝品應用與管理系(所)] 期刊論文 [生物科技系(所)] 期刊論文

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