The Rate of Appearance and Disappearance of Plasma Muscle Creatine Phosphokinase in Rabbits after Intramuscular Administration of Sulpyrine Injection

Chia Nan University of Pharmacy & Science Institutional Repository > 嘉南學報 > 9 期 (1983) > Item 310902800/25964

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標題:	The Rate of Appearance and Disappearance of Plasma Muscle Creatine Phosphokinase in Rabbits after Intramuscular Administration of Sulpyrine Injection 肌肉注射斯而比林後家兔血清中CPK酶活性之出現及消失速度
作者:	Chao-Hsiung Wang Hanjong Pern Hsingchu Hsu
日期:	1983
上傳時間:	2012-11-16 09:01:50 (UTC+8)
摘要:	The appearance and disappearance profile of plasma CPK in rabbits after intramuscular administration of 25% (w/v) of sulpyrine injection was demonstrated with seven rabbits. The profiles in five rabbits showed a biphasic pattem and could be fitted to an one-compartment open model whereas the remainder showed an erratic pattern. The mean rate constant of appearance (Kap) and disappearance (Kap) of CPK after sulpyrine injection were estimated to be 0.14 +- 0.047 (mean +- S.D.) and 0.062 +- 0.015 h-1.The regression equations obtained by the weighted damping Gauss-Newton method were presented.By using the estimation of 95% confidence intervals, Kap can be derived from the sum of Kdp and β (overall elimination rate constant from in bolus experiment).The result provides an approximate estimation for the Kap in the case ot erratic profile.
關聯:	嘉南學報 9, A1-A7 轉載自臺灣藥學雜誌, 34(2)
顯示於類別:	[嘉南學報] 9 期 (1983)

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