Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25513
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    CNU IR > Chna Nan Annual Bulletin > Vol.10 (1984) >  Item 310902800/25513
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/25513


    Title: The Implication of Thoracic Duct Lymph in the Distribution and Elimination of Rabbit Muscle Creatine Phosphokinase
    Authors: Hsingchu Hsu
    Jun Watanabe
    Contributors: 藥學科
    Keywords: rabbit muscle creatine phosphokinase
    thoracic duct lymph
    lymph flow
    transfer of CPK(plasma to lymph and muscle to lymph
    Date: 1984
    Issue Date: 2012-09-12 16:29:28 (UTC+8)
    Abstract: The implication of thoracic duct Iymph in the distribution and the elimination of rabbit muscle creatine phpsphokinase (CPK) was investigated in situ and in vitro with 30 rabbits. The rate of thoracic duct lymph flow per kg body weight in anesthetized rabbits was 0.97+-0.21ml.h-1.kg-1 (mean +- S.D., n=9). The CPK activity (U) that appeared in thoracic duct lymph after laparotomy (15 cm dissection along the mid-line) was 0.129 +- 0.038 U/h (n = 4) in untreated rabbits and 4.55 +- 2.23 U/h (n=5) in rabbits given intramuscular administration of CPK(1000U/kg body weight). The rate of transfer of CPK from the circulation to the thoracic duct lymph in rabbits after intravenous administration of CPK (1000 U/kg) was 30.0 +- 11.1 U/h (n=5).The inactivation rate constant of CPK in thoracic duct lymph (pH 7.40, 39℃,0.098 +- 0.023 h-1, n= 5) was larger than that in heparinized whole blood. The result implies that CPK may be partly inactivated in the lymph in vivo. The inactivation rate constant of CPK in thoracic duct lymph fluid without lymphocytes (pH 7.40, 0.159 +-0.013h-1, n=3) was much larger than that in the thoracic duct lymph. The calcium conceotration (14.4 +- 0.8l0mg/dl, n=7)and the magnesium concentration (3.93 +- 0.530mg/dl, n=7) in thoracic duct lymph were determined. The possible mechanism involved in the inactivation of CPK in thoracic duct lymph is discussed.
    Relation: 嘉南學報 10期 : p.A8-A15 轉載 Chem Pharm Bull (Tokyo) 31(9) p.3269-3276
    Appears in Collections:[Chna Nan Annual Bulletin] Vol.10 (1984)
    [Dept. of Pharmacy] Periodical Articles

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