The Effect of Disposition Model on the Estimation of Micro-Rate Constants of Rabbit Muscle Creatine Phosphokinase

CNU IR > Chna Nan Annual Bulletin > Vol.10 (1984) > Item 310902800/25512

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Title:	The Effect of Disposition Model on the Estimation of Micro-Rate Constants of Rabbit Muscle Creatine Phosphokinase 體內動態模式對家兔肌肉Creatine Phosphokinase之微速度定數推定值之影響
Authors:	Hsingchu Hsu Chao-Hsiung Wang
Contributors:	藥學科
Keywords:	肌肉兔定數值動態推定速度微影響模式體內
Date:	1984
Issue Date:	2012-09-12 16:29:27 (UTC+8)
Abstract:	Mathematic manipulation was performed on the pharmacokinetic equation parameters of CPK after intravenous administration of 300, 500 and 860 U/kg body weight dose in sixteen male rabbits to investigate the effect of disposition model with or without the involvement of inactivation in the Iymphatic system on the micro-rate constants of CPK. The pharmacokinetic equations and the estimation of micro-rate constants were derived for two distinct two-compartment body models. The mean hybrid distribution rate constant (α) and elimination rate constant (β) were 0.630 +- 0.176 h-1(mean +- S.D., n = 16) and 0.106 +- 0.016 h-1, and were independent on the dose size.The mean micro-rate constants for the model involving an apparent first-order inactivation process of CPK in the Iymph were estimated to be 0.092 +- 0.038 h-1 (k10), 0.245 +- 0.061 (k12) and 0.321 +- 0.146 h-1 (k2l). Student t-test showed the difference of the micro-rate constants among the different dose size and between the two models was insignificant due to the relatively large intersubject variability in rabbits. However,the result of kinetic analysis implied the possible involvement of reticuloendothelial system in the elimination of CPK in vivo.
Relation:	嘉南學報 10期 : p.A1-A7 轉載台灣藥學雜誌 35(2) p.125-131
Appears in Collections:	[Chna Nan Annual Bulletin] Vol.10 (1984)

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