Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25507
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17775/20116 (88%)
Visitors : 10185750      Online Users : 442
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    CNU IR > Chna Nan Annual Bulletin > Vol.10 (1984) >  Item 310902800/25507
    Please use this identifier to cite or link to this item:

    Synthetic Studies on Bromopavine and Phenolic Monopavine
    Authors: 莊世憲
    Contributors: 藥學科
    Date: 1984
    Issue Date: 2012-09-12 16:29:22 (UTC+8)
    Abstract: 為提供合成各種Bispavine類衍生物,乃從事Bromopavine及Phenolic monopavines之合成研究。分別以3-Hydr oxybenzalde hyde及Vanillin為起始物,經數步反應形成Phenylethylamines之衍生物(Ⅶa,b,c)然後將此Ⅶa及VIIc與3,4-Dimethoxyphenyl acetic acid (VIIIa ), VIIb及VIIc與m-Methoxyphenyl acetic acid (Ⅷ b)縮合成醯胺類衍生物(Ⅸa,b,c,d),經Bischler - Napieralski環化反應,得異喹啉衍生物( Xa,b,c,d )。將其製成N一甲基碘鹽( XIa,b,c,d )後,經部分還原得N一甲基一l, 2一二氫基異喹啉(Ⅶa,b,c,d),然後在酸催化下,XIIa,b 環化成2, 8, 9-Trimethoxy-N-methylpavinane ( Ia ), XIIc,d環化成二個Phenolic monopavines 2, 8 - Dimethoxy-9-hydroxypavinane( Ib )及(±) -Norargemonine ( Ic )。再將Pavine Ia進行溴化反應,得到Mono-bromopavineⅡa。此溴化反應具有Regiospecific之特性,溴取代在苯環C-1的位置。日後之研究,可試將Monobromopavine II與Phenolic monopavines ( Ib及Ic )以Ullmann condensation結合成二種Bispavines.或試將二個Phenolic monopavines ( Ib及Ic )溴化為Monobromophenolic pavine,再與Ib及Ic進行Ullmann condensation結合成各種Bispavines,以提供各種Pavines雙聚合體之物理、化學、生物活住之研究。
    Relation: 嘉南學報 10期 : p.31-46
    Appears in Collections:[Chna Nan Annual Bulletin] Vol.10 (1984)
    [Dept. of Pharmacy] Periodical Articles

    Files in This Item:

    There are no files associated with this item.

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback