Unraveling polyketide synthesis in members of the genus Aspergillus

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Title:	Unraveling polyketide synthesis in members of the genus Aspergillus
Authors:	Yi-Ming Chiang Berl R. Oakley Nancy P. Keller Clay C. C. Wang
Contributors:	藥物科技研究所
Keywords:	Secondary metabolites Fungi Polyketide Nonribosomal peptides
Date:	2010-05
Issue Date:	2012-06-04 16:40:19 (UTC+8)
Abstract:	Aspergillus species have the ability to produce a wide range of secondary metabolites including polyketides that are generated by multi-domain polyketide synthases (PKSs). Recent biochemical studies using dissected single or multiple domains from PKSs have provided deep insight into how these PKSs control the structural outcome. Moreover, the recent genome sequencing of several species has greatly facilitated the understanding of the biosynthetic pathways for these secondary metabolites. In this review, we will highlight the current knowledge regarding polyketide biosynthesis in Aspergillus based on the domain architecture of non-reducing, highly reducing, and partially reducing PKSs, and PKS-non-ribosomal peptide synthetases.
Relation:	Applied Microbiology and Biotechnology 86(6)：p.1719-1736
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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