Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25390
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    题名: The systemic toxicity of equipotent proxymetacaine, oxybuprocaline, and bupivacaline during continuous intravenous infusion in rats
    作者: Intravenous Infusion in Rats Ching-Hsia Hung
    Kuo-Sheng Liu
    Dong-Zi Shao
    Kuang-I Cheng
    Yu-Chung Chen
    Yu-Wen Chen
    贡献者: 藥物科技研究所
    日期: 2010-01
    上传时间: 2012-06-04 16:40:18 (UTC+8)
    摘要: BACKGROUND: Although proxymetacaine and oxybuprocaine produce topical ocular and spinal anesthesia, they have never been tested as cutaneous anesthetics. We compared cutaneous analgesia of proxymetacaine and oxybuprocaine with bupivacaine and tested their central nervous system and cardiovascular toxicity.

    METHODS: After blockade of cutaneous trunci muscle reflex with subcutaneous injections, we evaluated the local anesthetic effect of proxymetacaine and oxybuprocaine on cutaneous analgesia in rats. After IV infusions of equipotent doses of oxybuprocaine, proxymetacaine, and bupivacaine, we observed the onset time of seizure, apnea, and impending death and monitored mean arterial blood pressure and heart rate.

    RESULTS: Proxymetacaine and oxybuprocaine acted like bupivacaine and produced dose-related cutaneous analgesia. On a 50% effective dose basis, the ranks of potencies were proxymetacaine > oxybuprocaine > bupivacaine (P < 0.01). Under equipotent doses, the infusion times of proxymetacaine or oxybuprocaine required to cause seizure, apnea, and impending death were longer than that of bupivacaine (P < 0.05). The decrease in mean arterial blood pressure and heart rate was slower with oxybuprocaine and proxymetacaine compared with bupivacaine (P < 0.05 for the differences) at equipotent doses.

    CONCLUSIONS: Oxybuprocaine and proxymetacaine were more potent at producing cutaneous anesthesia but were less potent than bupivacaine at producing central nervous system and cardiovascular toxicity.
    關聯: Anesthesia & Analgesia 110(1)：p.238-242
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