The systemic toxicity of equipotent proxymetacaine, oxybuprocaline, and bupivacaline during continuous intravenous infusion in rats

doi:10.1213/ANE.0b013e3181bf6acf

CNU IR > Pharmacy and Science > Dept. of Pharmacy > Periodical Articles > Item 310902800/25390

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Title:	The systemic toxicity of equipotent proxymetacaine, oxybuprocaline, and bupivacaline during continuous intravenous infusion in rats
Authors:	Intravenous Infusion in Rats Ching-Hsia Hung Kuo-Sheng Liu Dong-Zi Shao Kuang-I Cheng Yu-Chung Chen Yu-Wen Chen
Contributors:	藥物科技研究所
Date:	2010-01
Issue Date:	2012-06-04 16:40:18 (UTC+8)
Abstract:	BACKGROUND: Although proxymetacaine and oxybuprocaine produce topical ocular and spinal anesthesia, they have never been tested as cutaneous anesthetics. We compared cutaneous analgesia of proxymetacaine and oxybuprocaine with bupivacaine and tested their central nervous system and cardiovascular toxicity. METHODS: After blockade of cutaneous trunci muscle reflex with subcutaneous injections, we evaluated the local anesthetic effect of proxymetacaine and oxybuprocaine on cutaneous analgesia in rats. After IV infusions of equipotent doses of oxybuprocaine, proxymetacaine, and bupivacaine, we observed the onset time of seizure, apnea, and impending death and monitored mean arterial blood pressure and heart rate. RESULTS: Proxymetacaine and oxybuprocaine acted like bupivacaine and produced dose-related cutaneous analgesia. On a 50% effective dose basis, the ranks of potencies were proxymetacaine > oxybuprocaine > bupivacaine (P < 0.01). Under equipotent doses, the infusion times of proxymetacaine or oxybuprocaine required to cause seizure, apnea, and impending death were longer than that of bupivacaine (P < 0.05). The decrease in mean arterial blood pressure and heart rate was slower with oxybuprocaine and proxymetacaine compared with bupivacaine (P < 0.05 for the differences) at equipotent doses. CONCLUSIONS: Oxybuprocaine and proxymetacaine were more potent at producing cutaneous anesthesia but were less potent than bupivacaine at producing central nervous system and cardiovascular toxicity.
Relation:	Anesthesia & Analgesia 110(1)：p.238-242
Appears in Collections:	[Dept. of Pharmacy] Periodical Articles

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