Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25385
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 17776/20117 (88%)
Visitors : 10938513      Online Users : 223
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item:

    Title: Characterization of the Aspergillus nidulans monodictyphenone gene cluster
    Authors: Yi-Ming Chiang
    Edyta Szewczyk
    Ashley D. Davidson
    Ruth Entwistle
    Nancy P. Keller
    Clay C. C. Wang
    Berl R. Oakley
    Contributors: 藥物科技研究所
    Date: 2010-04
    Issue Date: 2012-06-04 16:40:11 (UTC+8)
    Publisher: Amer Soc Microbiology
    Abstract: Deletion of cclA, a component of the COMPASS complex of Aspergillus nidulans, results in the production of monodictyphenone and emodin derivatives. Through a set of targeted deletions in a cclA deletion strain, we have identified the genes required for monodictyphenone and emodin analog biosynthesis. Identification of an intermediate, endocrocin, from an mdpHΔ strain suggests that mdpH might encode a decarboxylase. Furthermore, by replacing the promoter of mdpA (a putative aflJ homolog) and mdpE (a putative aflR homolog) with the inducible alcA promoter, we have confirmed that MdpA functions as a coactivator. We propose a biosynthetic pathway for monodictyphenone and emodin derivatives based on bioinformatic analysis and characterization of biosynthetic intermediates.
    Relation: Applied and Environmental Microbiology 76(7):p.2067-2074
    Appears in Collections:[Dept. of Biotechnology (including master's program)] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    99_157_j.pdf1112KbAdobe PDF429View/Open

    All items in CNU IR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback