Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25385
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    Title: Characterization of the Aspergillus nidulans monodictyphenone gene cluster
    Authors: Yi-Ming Chiang
    Edyta Szewczyk
    Ashley D. Davidson
    Ruth Entwistle
    Nancy P. Keller
    Clay C. C. Wang
    Berl R. Oakley
    Contributors: 藥物科技研究所
    Date: 2010-04
    Issue Date: 2012-06-04 16:40:11 (UTC+8)
    Publisher: Amer Soc Microbiology
    Abstract: Deletion of cclA, a component of the COMPASS complex of Aspergillus nidulans, results in the production of monodictyphenone and emodin derivatives. Through a set of targeted deletions in a cclA deletion strain, we have identified the genes required for monodictyphenone and emodin analog biosynthesis. Identification of an intermediate, endocrocin, from an mdpHΔ strain suggests that mdpH might encode a decarboxylase. Furthermore, by replacing the promoter of mdpA (a putative aflJ homolog) and mdpE (a putative aflR homolog) with the inducible alcA promoter, we have confirmed that MdpA functions as a coactivator. We propose a biosynthetic pathway for monodictyphenone and emodin derivatives based on bioinformatic analysis and characterization of biosynthetic intermediates.
    Relation: Applied and Environmental Microbiology 76(7):p.2067-2074
    Appears in Collections:[Dept. of Biotechnology (including master's program)] Periodical Articles

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