Percutaneous absorption of piroxicam from ointment bases in rabbits

CNU IR > Chna Nan Annual Bulletin > Vol.11 (1985) > Item 310902800/25273

請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/25273

題名:	Percutaneous absorption of piroxicam from ointment bases in rabbits
作者:	Yi-Hung Tsai Li-Ren Hsu Shun-Ichi Natio
貢獻者:	藥學科
日期:	1985
上傳時間:	2012-05-24 11:00:44 (UTC+8)
摘要:	In order to investigate the process of percutaneous absorption from various ointment bases, the blood levels of piroxicam were determined at optimal intervals after the ointment application in rabbtts. After the oral and intravenous administrations, the plasma levels of piroxicam were described by the two-compartment model. A pharmacokinetic model similar to the percutaneous absorption of indomethacin was developed to test the concepts regarding the percutaneous absorption of piroxicam from topical ointment bases. A reasonably good fit between experimental and calculated values was obtained by taking into account identical absorption rate constant (Ka) and the changes in drug release constant (Kr) and the fraction of drug absorbed (F). We found that piroxicam in the o/w ointment base (UCH ointment containing12% propylene glycol) had a better percutaneous absorption effect than the other three different kinds of ointment bases which were a simple ointment, PEG ointment and petrolatum rosewater Ointment.The pH value of the water phase in UCH ointment containing 12% propylene glycol was adjusted to pH 9.2 by the sodium bicarbonate-buffered solution, then the percutaneous absorption of piroxicam could be increased. The effect of the amount of Piroxicam on the percutaneous absorption was also investigated.The optimal effect with the additives in the ointment was finally attained with an addition of 5% urea.
關聯:	嘉南學報 11期：p.A1-A18 轉載 International journal of pharmaceutics 24(1985) p.61-78
顯示於類別:	[Chna Nan Annual Bulletin] Vol.11 (1985) [Dept. of Pharmacy] Periodical Articles

文件中的檔案:

沒有與此文件相關的檔案.

在CNU IR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....