Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25221
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    標題: Conjugated linoleic acid causes a marked increase in liver a-tocopherol and liver a-tocopherol transfer protein in C57BL/6J mice
    作者: Pei-Min Chao
    Wan-Hsuan Chen
    Chun-Huei Liao
    Huey-Mei Shaw
    貢獻者: 保健營養系
    關鍵字: Conjugated linoleic acid
    a-tocopherol
    a-tocopherol transfer protein
    mice
    antioxidant enzyme
    日期: 2010-02
    上傳時間: 2012-05-21 16:29:59 (UTC+8)
    摘要: Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers
    of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate
    whether levels of hepatic a-tocopherol, a-tocopherol transfer protein (a-TTP), and antioxidant
    enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the
    CLA and control groups, which were fed, respectively, a 5% fat diet with or without 1 g/100 g of CLA
    (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. a-Tocopherol levels in plasma and
    liver were significantly higher in the CLA group than in the control group. Liver a-TTP levels were also
    significantly increased in the CLA group, the a-TTP/b-actin ratio being 2.5-fold higher than that in
    controlmice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA
    group (p<0.01). There were no significant differences between the two groups in levels of three
    antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation
    of liver a-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and
    the ability of a-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced
    lipid peroxidation in the liver of CLA mice are due to a-tocopherol accumulation.
    關聯: International Journal for Vitamin and Nutrition Research 80(1)：p.65-73
    显示于类别:[保健營養系(所) ] 期刊論文

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