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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/25137

    標題: Apoptosis effect of Sinularia leptoclados, S. depressan and S. inflate extracts in human oral squamous cell carcinomas
    作者: Chia-Hua Liang
    Guey-Horng Wang
    Wei-Jing Hung
    Rong-Jyh Lin
    Da-Long Cheng
    Tzung-Han Chou
    貢獻者: 化粧品應用與管理系
    關鍵字: Sinularia leptoclados
    Sinularia depressan
    Sinularia inflate
    Human oral squamous cell carcinoma
    日期: 2010-01
    上傳時間: 2012-03-29 13:45:53 (UTC+8)
    摘要: This work demonstrates the toxic effects of Sinularia leptoclados. Sinularia depressan and Sinularia inflate extracts on human oral squamous cell carcinoma (SCC4, SCC9 and SCC25) cells using cell adhesion and cell viability assays. The three extracts inhibited growth of human SCC25 (which exhibited effective differentiation) cells than they did SCC4 (moderate differentiation) and SCC9 (poor differentiation) cells. The morphological changes of the SCC25 cells upon treatment with the three extracts were caused by apoptosis, as determined from the morphological features (spheroid shape, chromatin condensation and formation of apoptotic bodies). Flow cytometry indicates that three extracts sensitized SCC25 cells in the G2/M phases with a concomitantly and significantly increased fraction of sub-G1. This investigation reveals that apoptosis that occurred when the SCC cells were treated with S. leptoclados, S. depressan and S. infllate extracts was accompanied by up-regulation of p53 and activation of caspase-3 expression.
    關聯: Journal of the Taiwan Institute of Chemical Engineers 41(1):p.86-91
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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