Analgesic and anti-inflammatory activities of an ethanol extract of Dunaliella salina Teod. (Chlorophyceae)

doi:10.1111/j.1745-4514.2010.00389.x

Chia Nan University of Pharmacy & Science Institutional Repository > 藥理學院 > 化妝品應用與管理系(所) > 期刊論文 > Item 310902800/25136

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標題:	Analgesic and anti-inflammatory activities of an ethanol extract of Dunaliella salina Teod. (Chlorophyceae)
作者:	Pei-Yu Chou Yi-Chung Chien Jwo-Sheng Chen Ming-Hsing Huang Kai-Jeng Hsu Ming-Jyh Sheu
貢獻者:	化粧品應用與管理系
日期:	2010-12
上傳時間:	2012-03-29 13:45:53 (UTC+8)
出版者:	Wiley-Blackwell
摘要:	This study investigated the analgesic and anti-inflammatory effects of an ethanol extract of Dunaliella salina Teod. (Chlorophyceae) (EDS) in Imprinting Control Region mice. Standard all-trans-β-carotene and the amount of all-trans-β-carotene in an EDS were analyzed by high-performance liquid chromatography (HPLC). In HPLC analysis, the fingerprint chromatogram of EDS was established. Both all-trans-β-carotene and EDS showed similar peaks at the retention time of 24 min. This implied that EDS contained the active ingredient all-trans-β-carotene. Treatment of animals with EDS significantly inhibited the numbers of acetic acid-induced writhing responses at doses of 0.5 g/kg (P < 0.01), 1.0 g/kg (P < 0.001) and 2.0 g/kg (P < 0.001). This inhibitory effect of EDS (1.0 and 2.0 g/kg) on acetic acid-induced writhings was similar to that of the positive control indomethacin (10 mg/kg) (P < 0.001). EDS did not significantly inhibit the formalin-induced pain in the early phase; however, at doses of 0.1 g/kg (P < 0.01), 0.5, 1.0 and 2.0 g/kg, EDS significantly inhibited the formalin-induced pain in the late phase (P < 0.001). Finally, EDS at doses of 1.0 and 2.0 g/kg also inhibited the development of paw edema induced by λ-carrageenan (carrageenan). EDS (1.0 and 2.0 mg/kg) decreased the level of nitiric oxide (NO) in edematous paw tissue and in serum level, and diminished the level of serum tumor necrosis factor-α (TNF-α) at the fifth hour after carrageenan injection. Based on these findings, EDS probably exerts anti-inflammatory effects by suppressing TNF-α and NO. These results suggest that EDS might be a potential pharmacological analgesic and anti-inflammatory agent.
關聯:	Journal of Food Biochemistry 34(6)：p.1288-1302
显示于类别:	[化妝品應用與管理系(所)] 期刊論文

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