Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/25132
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    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/25132


    Title: Antioxidant and antimelanogenic properties of rosmarinic acid methyl ester from Origanum vulgare
    Authors: Hsiou-Yu Dinga
    Tzung-Han Choub
    Chia-Hua Liang
    Contributors: 化粧品科技研究所
    Keywords: Antioxidant
    Antimelanogenic
    Origanumvulgare
    Rosmarinicacidmethylester
    Date: 2010-11
    Issue Date: 2012-03-29 13:45:49 (UTC+8)
    Abstract: Rosmarinicacidmethylester (Ov-8) was isolated form Origanumvulgare. The antioxidant activities of Ov-8 were evaluated by measuring radical-scavenging activities, reducing power, and inhibition of lipid peroxidation, using liposomes and mice tissue. The percentage inhibition, by Ov-8, of the activities of reactive oxygen species (ROSs) in H2O2-treated BNLCL2 cells was about 116.0–82.3% of that in H2O2-treated cells. The ability of Ov-8 to reduce tyrosinase, DOPA oxidase and melanin contents in B16 cells exceeded those of arbutin and l-ascorbic acid. Ov-8 reduced the expressions of the melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related proteins-2 (TRP-2) and TRP-1 in B16 cells. Applying Ov-8-gel to mice increased L∗ and reduced the erythema (E∗) and melanin (M∗) indices in relation to those of the base-gel and untreated groups. These results suggest that Ov-8 exhibits antioxidant and depigmentation activities that may be useful in food additives and in the control of skin pigmentation.
    Relation: Food Chemistry 123(2) ： p254-262
    Appears in Collections:[Dept. of Cosmetic Science and institute of cosmetic science] Periodical Articles

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