同半胱胺酸於細胞缺氧與動物熱中風模式中對細胞介質素和自由基之影響

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標題:	同半胱胺酸於細胞缺氧與動物熱中風模式中對細胞介質素和自由基之影響 Effects of Homocysteine on Expression of Cytokines and Free Radicals in Cell Culture under Hypoxic Condition and the Animal Heatstroke Model
作者:	劉家全溫義嗣
貢獻者:	化妝品應用與管理系
關鍵字:	高同半胱胺酸血症熱中風葉酸與維生素B12 缺氧/缺血 hyperhomocysteinemia heatstroke folic acid and vitamin-B12 hypoxia/ischemia
日期:	2010
上傳時間:	2011-12-22 09:47:24 (UTC+8)
摘要:	事先飲食補充葉酸與維生素B12 對高同半胱胺酸血症大鼠(經由餵食高單位甲硫胺酸所誘發)改善熱中風病理生理參數變化和傷害影響之探討--- 我們經由給予飲食處理高單位甲硫胺酸，來提升大鼠血中同半胱胺酸濃度誘發生成高同半胱胺酸血症，並評估對大鼠熱中風所致損傷的影響情況。在此一試驗中，我們再次確認HCY 參與在熱中風所致損傷病理生理發展的角色，而且證實高同半胱胺酸血症可能可視為是熱中風發生率的危險因子。我們推論HCY 不僅是心血管和神經疾病熟知的危險因子，也可能是與促進細胞介質素和自由基有關熱中風的危險因子。目前，沒有一個治療策略可以完全改善熱中風所造成的損傷，因此從日常預防觀點來減低熱中風的發生率和死亡率是很重要的。充足的葉酸與維生素B12 狀態可透過飲食補充，在降低血中高濃度HCY 扮演重要角色。現今實驗成果，我們論證在高同半胱胺酸血症大鼠中，經飲食補充葉酸和維生素-B12 後，可透過減低上升的細胞介質素和自由基，而達到改善因熱中風所致循環休克、腦缺氧、缺血和神經損傷的情形。 Investigation of effects of the folic acid and vitamin-B12 dietary supplementation in advance on improving the pathophysiologic parameters changes and damage during heatstroke in hyperhomocysteinemic rats (induced by feeding with diet of high content methionine). We raised the systemic levels of HCY to produce circulating hyperhomocysteinemia via giving high content methionine diet, and then estimate the influence on the heatstroke-induced damage in rats. In this experiment, we confirm again the role of HCY in pathophysiologic development of heatstroke-induced damage, and demonstrated that hyperhomocysteinemia may be viewed as a risk factor for heatstroke incidence. We speculate that HCY, a known risk factor for other cardiovascular and neuronal diseases, can be also a risk factor for heatstroke associated with the increased cytokines and free radicals. Until now, no one therapeutic strategy could be effective to completely improve the heatstroke-induced damage. It will be more important to diminish the heatstroke incidences and mortality rate from the viewpoint in regular prophylaxis. The sufficient folate and vitamin-B12 statuses, which can be achieved through folate and vitamin-B12 dietary supplementation, may play a critical role in lowering elevated HCY concentrations. In present study, we found that dietary supplementation with folic acid and vitamin-B12 in rats with hyperhomocysteinemia may ameliorate the heatstroke-induced circulatory shock, cerebral hypoxia, ischemia and neuronal damage by attenuating the increased cytokines and free radicals.
關聯:	計畫編號：NSC97-2314-B041-001-MY3 計畫年度：99；起迄日期：2010-08-01~2011-07-31 核定金額：950,000元
顯示於類別:	[化妝品應用與管理系(所)] 科技部計畫

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