事先飲食補充葉酸與維生素B12 對高
同半胱胺酸血症大鼠(經由餵食高單
位甲硫胺酸所誘發)改善熱中風病理
生理參數變化和傷害影響之探討---
我們經由給予飲食處理高單位甲硫胺
酸，來提升大鼠血中同半胱胺酸濃度
誘發生成高同半胱胺酸血症，並評估
對大鼠熱中風所致損傷的影響情況。
在此一試驗中，我們再次確認HCY 參
與在熱中風所致損傷病理生理發展的
角色，而且證實高同半胱胺酸血症可
能可視為是熱中風發生率的危險因
子。我們推論HCY 不僅是心血管和神
經疾病熟知的危險因子，也可能是與
促進細胞介質素和自由基有關熱中風
的危險因子。目前，沒有一個治療策
略可以完全改善熱中風所造成的損
傷，因此從日常預防觀點來減低熱中
風的發生率和死亡率是很重要的。充
足的葉酸與維生素B12 狀態可透過飲
食補充，在降低血中高濃度HCY 扮演
重要角色。現今實驗成果，我們論證
在高同半胱胺酸血症大鼠中，經飲食
補充葉酸和維生素-B12 後，可透過減
低上升的細胞介質素和自由基，而達
到改善因熱中風所致循環休克、腦缺
氧、缺血和神經損傷的情形。 Investigation of effects of the folic acid
and vitamin-B12 dietary
supplementation in advance on
improving the pathophysiologic
parameters changes and damage during
heatstroke in hyperhomocysteinemic
rats (induced by feeding with diet of
high content methionine). We raised the
systemic levels of HCY to produce
circulating hyperhomocysteinemia via
giving high content methionine diet, and
then estimate the influence on the
heatstroke-induced damage in rats. In
this experiment, we confirm again the
role of HCY in pathophysiologic
development of heatstroke-induced
damage, and demonstrated that
hyperhomocysteinemia may be viewed
as a risk factor for heatstroke incidence.
We speculate that HCY, a known risk
factor for other cardiovascular and
neuronal diseases, can be also a risk
factor for heatstroke associated with the
increased cytokines and free radicals.
Until now, no one therapeutic strategy
could be effective to completely
improve the heatstroke-induced damage.
It will be more important to diminish the
heatstroke incidences and mortality rate
from the viewpoint in regular
prophylaxis. The sufficient folate and
vitamin-B12 statuses, which can be
achieved through folate and
vitamin-B12 dietary supplementation,
may play a critical role in lowering
elevated HCY concentrations. In present
study, we found that dietary
supplementation with folic acid and
vitamin-B12 in rats with
hyperhomocysteinemia may ameliorate
the heatstroke-induced circulatory shock,
cerebral hypoxia, ischemia and neuronal
damage by attenuating the increased
cytokines and free radicals.
