新型Fe3O4/living block copolymer之合成及其自組裝微胞型態與藥物釋放之研究

CNU IR > Pharmacy and Science > Dept. of Cosmetic Science and institute of cosmetic science > MOST Project > Item 310902800/24836

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Title:	新型Fe3O4/living block copolymer之合成及其自組裝微胞型態與藥物釋放之研究 The Study of the Synthesis and Self-Assembly of Novel Fe3O4/Living Block Copolymer and Its Application on Drug Release
Authors:	李佳芬
Contributors:	化妝品應用與管理系
Keywords:	活性自由基聚合反應自組裝有機/無機複合微胞酸鹼感應性溫度感應性藥物控制釋放 living radical polymerization self-assembly organic/inorganic composite micelle pH sensitive thermo-sensitive drug control release
Date:	2010
Issue Date:	2011-12-22 09:46:41 (UTC+8)
Abstract:	本計畫預計以三年時間完成。計畫內容將以controlled/living radical polymerization (C/LRP)方式合成出具有溫度感應性以及具有pH感應性的living block copolymer ，此 living block copolymer會受到溫度以及pH值的影響而改變其親水性與疏水性，藉由此特性living block copolymer 即可在水中進行self-assembly形成微胞，在本計劃中預計在 living block copolymer存在之下合成Fe3O4，以製備出表面接有Fe3O4而且具有溫度感應性及pH感應特性的有機/無機Fe3O4 /block copolymer磁性複合微胞。並以此Fe3O4 /block copolymer磁性複合微胞作為載體，將藥物包覆於其內部，由於此微胞接有Fe3O4而Fe3O4 是一種磁性材料,因此在磁場的作用引導下，Fe3O4 /block copolymer磁性複合微胞載體會隨著磁場的引導而到達病變組織,此外根據研究顯示Fe3O4 磁性奈米粒子於交流電場下具有良好的發熱特性，因此我們可以利用此發熱特性使得block copolymer中具溫度感應性的polymer chains產生收縮，而將內部所包覆的藥物擠出來，針對病變組織做直接的治療，如此達到標的治療的功效。另外由於Fe3O4的磁性奈米粒子於交流電場下具有良好的發熱特性，因而也具有臨床的腫瘤熱炙治療效果，直接藉由Fe3O4所發出的熱源來破壞腫瘤組織細胞，而達到治療腫瘤組織的目的。本計畫第一年將進行bulk 或solution polymerization 的C/LRP，來合成出living block copolymer ，此living block copolymer 中包含具溫度感應性的N-isopropylacrylamide (NIPAAm) 以及具酸鹼感應性的methyl acrylic acid (MAA) 單體，如此所合成的 poly(NIPAAm)-poly(MAA) block copolymer不僅具有溫度感應性而且還具有酸鹼感應性等雙重特性，此living block copolymer會受到溫度及pH值的影響而呈現出不同的親水性與疏水性，利用此特性可使得living block copolymer一端呈現親水的特性而令一端呈現疏水的特性，如此living block copolymer即可進行self-assembly(自組裝)而形成高分子微胞(polymer micelle)，在此研究中將詳加探討各種實驗變因對於高分子微胞型態結構的影響。計畫第二年接續第一年的研究成果，在living block copolymer 存在之下合成磁性 Fe3O4奈米顆粒，使Fe3O4奈米顆粒接在living block copolymer上，再經由block copolymer 的self-assembly製備出Fe3O4 /block copolymer有機/無機磁性複合微胞，在此研究中將詳加探討各種實驗變因對於Fe3O4 /block copolymer 磁性複合微胞型態結構及安定性的影響。計畫第三年接續第二年的研究成果將第二年研究所合成的Fe3O4 /block copolymer磁性複合微胞作為載體來包覆藥物，為了使微胞的結構能夠穩固，以穩定的載負藥物，因此我們將利用交聯劑2,2'-(ethylenedioxy)bis(ethylamine)與block copolymer中的P(MAA) 進行縮合反應，使微胞形成穩定的交聯結構。在此研究中將探討各種實驗變因對於微胞顆粒穩定性、型態結構、載藥效率，以及藥物釋放速率的影響。 This project is scheduled to be finished in three years. The method of control/living radical polymerization (C/L RP) is used to synthesize the living block copolymer with the properties of thermo-sensitive and pH sensitive. The factors of temperature and pH value may influence the hydrophilic property of living block copolymer, and therefore the block copolymer will self-assembly to form the polymer micelles. This project is planned to synthesize the Fe3O4 nanoparticles in the presence of block copolymer to form the organic/inorganic Fe3O4 /block copolymer magnetic composite micelles. The magnetic composite micelles are used as drug carriers to load with the oil soluble drug and water soluble drug. Because the polymer micelles combine with Fe3O4 so that the magnetic composite polymer micelles may target drug to specific sits through the selective application of a magnetic filed, that is magnetic targeted carriers. Besides, the magnetic targeted carriers can be applied on the magnetothermal therapy. The first year of this project is planned to synthesize the thermo-sensitive and pH sensitive block copolymer. Temperature and pH value can influence the hydrophilic property of block copolymer; base on this way the block copolymer may self-assembly and form the polymer micelles. The second year of this project is to synthesize the Fe3O4 magnetic nanoparticles in the presence of block copolymer to form the organic/inorganic Fe3O4 /block copolymer magnetic composite micelles. Various variances influence the morphology and properties of the magnetic polymer micelles are studied. In the third year of this project, the magnetic polymer micelles are used as drug carriers to load with either water soluble drug or oil soluble drug. The ability of the magnetic polymer micelles to control release the drug will be study.
Relation:	計畫編號：NSC99-2221-E041-004 計畫年度：99；起迄日期：2010-08-01~2011-07-31 核定金額：745,000元
Appears in Collections:	[Dept. of Cosmetic Science and institute of cosmetic science] MOST Project

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