本研究主要是以不同的方法製造幾丁聚醣(Chitosan)載體並以此載體來包覆胜肽(peptide)，然而已經知道幾丁聚醣(Chitosan)的分子量不同就有不一樣的特性以及應用範圍，而本研究則是以兩種不同的包覆方式並改變載體組成來探討幾丁聚醣(Chitosan)載體包覆胜肽量的多寡，結果顯示當三聚磷酸鈉(Sodium Tripolyphosphate)的濃度較大時，幾丁聚醣(Chitosan)包覆的孔隙較小使得包覆效果往下降低，除了知道三聚磷酸鈉(Sodium Tripolyphosphate)的濃度會影響包覆的孔徑大小之外，也發現載體製造方式及製造條件亦會影響孔徑大小與包覆效果。
膚質檢測載體包覆前後的效果差異性，兩者相比較則沒有明顯的差異，結果顯示膚質檢測載體包覆前後的受測者都會具有改善其淡化皺紋的效果。然而幾丁聚醣(Chitosan)已經被證實是具有抗菌效果，當幾丁聚醣(Chitosan)去乙醯化程度越高則具有抗菌的功效，而實驗在最後則利用抗菌試驗測試製成幾丁聚醣載體是否也具有其抗菌效果，其結果顯示只對於金黃色葡球菌有抑菌功效。 This study aims to manufacturing chitosan being a carrier coating peptide in different methods. However, chitosan with different molecular weight has different characteristics in different applications. Coating peptide by two ways and changing the composition of the carrier chitosan, this study researches the amount of peptide coated by the carrier. The results show that the higher the concentration of STPP, the smaller the pores chitosan coating. And it reduces the coating effect. In addition to the concentration of STPP, it also found the method of manufacturing carrier and manufacturing conditions will affect the pore size and coating effects.
There is no significant difference in skin testing before and after the carrier coating. The results of skin testing show it will improve the wrinkles fade before and after the subjects coated by the carrier. However, chitosan has been proven to have anti-bacterial effects. The higher the degree of chitosan distillation, the higher the anti-bacterial effect. Finally, the experiments use anti-bacterial testing to test whether the chitosan carrier has anti-bacterial effects. And the results show it has anti-bacterial effects only for the Staphylococcus aureus.
