N,O-Diacetyl-p-aminophenol之解熱、陣痛作用和急性毒性

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Title:	N,O-Diacetyl-p-aminophenol之解熱、陣痛作用和急性毒性 The antipyretic and analgesic effect, and acute toxicity of n,o-diacetyl-p-aminopeienol
Authors:	許延年高惠珍楊竹茂
Contributors:	藥學科
Keywords:	N,O-二乙醯基-對-胺苯酚解熱作用鎮痛作用急性毒性 N,O-diacetyl-p-aminophenol antipyretic effect analgesic effect acute toxicity
Date:	1987
Issue Date:	2011-10-24 14:27:32 (UTC+8)
Abstract:	乙醯水楊酸( Acetylsalicylic Acid, Aspirin )經口投藥而併用非那西汀(Phenacetin )或是乙醯胺苯酚( Acetam inophen )，在白兔和大白鼠血液中產生一種化合物N, O-二乙醯基 - 對- 胺苯酚 ( N,O-Diacetyl-p-aminophenol,DAPAP )。本篇論文係研究此化合物之解熱、鎮痛作用及其急性毒性。 (a)解熱作用: (1)DAPAP.180mg/kg經口投藥，對於酵母誘發的發熱大白鼠其解熱作用強度約相當於乙醯水楊酸的120mg/kg或是非那西汀之 l00mg/kg。動物給予經口投藥DAPAP時，對體溫之下降作用和乙醯胺苯酚相同，但腹腔給藥時較乙醯胺苯酚的作用強。 (b)鎮痛作用:利用酢酸誘發的Writhing方法，測得DAPAP之鎮痛作用較乙醯胺苯酚稍為強些。 (c)半致死劑量( LD 50 )分別為1540mg/kg (口服)和1480mg/kg (腹腔注射)。 N,O-Diactyl-p-aminophenol (DAPAP ) was formed in plasma of rats and rabbits after oral co-administration of aspirin with phenacetin,or with acetaminophen. In this study, the antipyretic effect, analgesic effect and the acute toxicity of DAPAP were investigated. In this paper we present some results : (a)The antipyretic effect : (I)DAPAP 180mg/kg was orally administered in yeast-febrile rats, the antipyretic potency was equivalent to aspirin 120mg/kg (p.o. ) or phenacetin l00mg/kg ( p.o. ). (2)The effect on temperature lowing was equivalent to acetaminophen when it was given orally, but was more potent than acetaminophen when it was given intraperitoneally. (b)The analgesic effect : DAPAP was slightly stronger than acetaminophen by using acetic-acid-induced writhing method. (c)LD50 of DAPAP were 1540mg/kg ( p.o. ) and 1480mg/kg ( i.p. ),respectively.
Relation:	嘉南學報 13：p.50-54
Appears in Collections:	[Chna Nan Annual Bulletin] Vol.13 (1987) [Dept. of Pharmacy] Periodical Articles

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