The Absolute Bioavailability of Rabbit Muscle Creatine Phosphokinase after Intramuscular Administration

CNU IR > Chna Nan Annual Bulletin > Vol.13 (1987) > Item 310902800/24396

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Title:	The Absolute Bioavailability of Rabbit Muscle Creatine Phosphokinase after Intramuscular Administration
Authors:	Hsingchu Hsu Jun Watanabe
Contributors:	藥學科
Keywords:	rabbit muscle creatine phosphokinase clearance/body weight intramuscular administration mean residence time mean absorption time variance of residence time fraction of absorption
Date:	1987
Issue Date:	2011-10-24 14:19:38 (UTC+8)
Abstract:	A two-period crossover study was carried out to dctermine the rate and the extent of bioavailability of rabbit muscle creatine phosphokinase (CPK) after intramuscular administration to six male rabbits. The plasma prohfile of CPK after intramuscular administration (500 U/kg body weight in 0.8 ml of 2% rabbit serum albumin solution into the vastus lateralis muscle) showed a plateau around 4--12 h. Intravenous administration of CPK was performed at doses of 300 and 500U/kg body weight.The mean clearance/body weight and Vd/body weight were 0.00604 +- 0.00094 l/h/kg (mean +-S.D., n=6) and 5.32 +- 1.47%, respectively. The mean residence time (MRTim) and mean absorption time (MATim) of CPK after intramuscular administrationwere 20.7 +- 4.2 and 11.9 +- 5.1 h, respectively. Since MATim was long relative to MRTim, the rate of bioavailability was slow and the residence time distribution appeared to be skewed. The value of MATim/MRTim, reflecting the contribution of moment of input function to the plasma activity of CPK, was 55.4 +- 11.6%. The variance of residence time (VRTim) and variance of absorption time( VATim) were 608 +- 107 and 505 +- 122 h2. The results imply that the aborption and disposition of CPK after intramuscular administration were rather complicated.The mean fraction of CPK absorbed. was 0.311 +- 0. 149. Presumably, the incomplete access of CPK to the systemic circulation was due to extravascular inactivation.
Relation:	嘉南學報 13：A32-A38 轉載 Chemical & pharmaceutical bulletin 32(5) : p.1922-1928 (1984)
Appears in Collections:	[Chna Nan Annual Bulletin] Vol.13 (1987) [Dept. of Pharmacy] Periodical Articles

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