Four New cis-Clerodane-type Furanoditerpenoids of the Dry Stem of Tinospora crispa

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Title:	Four New cis-Clerodane-type Furanoditerpenoids of the Dry Stem of Tinospora crispa
Authors:	Shih-Yun Chung (鍾士雲) Jin-Bin Wu (吳金濱) Sheng-Chu Kuo (郭盛助) Chih-Chuang Liaw (廖志中)
Date:	2011
Issue Date:	2011-06-23 14:57:48 (UTC+8)
Abstract:	Tinospora crispa (Lour.) Merr (Menispermaceae) is a folk medicine wildly used in Thailand, Malaysia, Indonesia and China to treat jaundice, rheumatism, urinary disorders, and, especially, diabetes mellitus, and is regarded as one of valuable traditional Chinese medicine in China. Our preliminary bioassay test indicated that the methanol extract of both the stems and leaves of this plant showed a dose-dependent effect to stimulate insulin excretion of β-cells. In the previous study, we found Af-formylnornucidferine and cycloeucalenol showed the stimulation of insulin secretion of b-cells. In addition, borapetosides A and C showed the protective effect on the viability ofβ-cells under the treatment of dexamethasone, a glucocorticoid that promotes cell death. Continuing in the study on this plant, tour new clerodane-type fliranoditerpenoids 1-4, as well as 10 known compounds, were isolated from the methanol extract of the dry stem. Herein, we will report the structure elucidation of these new compounds by ID, and 2D-NMR, and other spectra. The biologic activity of these isolates are under investigation.
Relation:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
Appears in Collections:	[Pharmacy and Science] 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium

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