Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/24255
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    標題: Vasodilator Effect of Different Extractive Methods of Ginger extracts on jrorcine coronary Arteries
    作者: Ming-Chi Hung (洪明吉)
    Po-ChuenShieh (謝博銓)
    Fu-An Chen (陳福安)
    Hsu-shoucheng (徐守正)
    Sh-Ben Wang (王翠彬)
    Daih-Huang Kuo (郭代磺)
    日期: 2011
    上傳時間: 2011-06-23 14:57:40 (UTC+8)
    摘要: An investigation into the vasodilator effects of chloroform, n-butanol and reverse osmosis water extraction of the extracts of ginger {Zingiber officinale Rose.) on porcine coronary arteries. The right coronary arteries were harvested from a local slaughterhouse , carefully dissected out, and cut into 5-mm rings. All rings were subjected stepwise to a predetermined optimal tension of 3 g and allowed to equilibrate for 30 minutes. Alter equilibration, each ring was induced contraction by potassium chloride. The vasodilator curves were obtained with 5 cumulative additions of extracts (1,3, 10, 30 and 100 ppm). Isometric tension was measured using Cyber 380 and Digidata 1320A instruments and readings were recorded in a computer system. Our result revealed that the extracts of n-butanol and reverse osmosis water extraction had hardly vasodilator effect. The relaxant extents of various doses chloroform extract (1, 3, 10, 30 and 100 ppm) were 6�5 - 19�10 - 40�9 - 70�9 - 100� 0%. The result demonstrates that chloroform extract of ginger possesses vasodilator activity in a dose dependant manner. The possibly physiological relaxation mechanisms involved, vascular protection, scavenging free radicals, anti-oxidative effect, anti-inflammatory activity and related physiological mechanisms will also be surveyed.
    關聯: 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
    顯示於類別:[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

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