| 標題: | Synthesis and Biological Evaluation of Agents |
| 作者: | Chia-Hao Lu (呂家豪)
Yi-Cheng Chan (詹沂澄)
Tzung-Han Tang (湯宗翰)
Fong-Pin Liang (梁峰賓)
P. Shin-Hun Juang (莊聲宏)
Chih-Shiang Chang (張誌祥) |
| 日期: | 2011 |
| 上傳時間: | 2011-06-23 14:57:39 (UTC+8) |
| 摘要: | 6-(Methoxyphenyl)tetrahydroindazol-4-one derivatives were synthesized and evaluated for antiproliferative activity. Structure-activity relationship was elucidated with various substitutions on the N-l aryl moiety of tetrahydroindazol-4-one. A novel N-2 aryl-substituted skeleton was established by microwave synthesis. The bioevaluative result was shown that the N-\ substituted tetrahydroindazol-4-one possessed more potential activity against human lung cancer cell (H226), leukemia (Jurkat cell), and nasopharyngeal carcinoma cell (NPC-TW01) in vitro than those of corresponding N-2 derivatives. The introduction of oxime moiety at 4-position of tetranyaroinaazoiones iea to a loss 01 me cyioiuAiactivity. |
| 關聯: | 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林 |
| 顯示於類別: | [藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會
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