Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/24253
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 17760/20057 (89%)
造访人次 : 8027715      在线人数 : 624
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cnu.edu.tw/handle/310902800/24253


    標題: Design and Synthesis of l-AryIpyrrolo[3,2-c]quinoline Derivatives as Potential Anticancer Agents
    作者: Hsing-Wen Lu (呂幸紋)
    Chien-Chin Huang (黃建智)
    Yi-Ling Hsu (徐宜伶)
    Hao-Lun Huang (黃皓倫)
    Hua-An Lin (林花安)
    Chun-Tang Chiou (邱俊棠)
    Grace Shiahuy Chen (陳香惠)
    日期: 2011
    上傳時間: 2011-06-23 14:57:38 (UTC+8)
    摘要: Combrestastatin A4 (CA-4) is a well known potent tubulin polymerization inhibitor. It is structurally similar to colchicines and competes on the position of microtubule with colchicines. The structural features of CA-4 possess two aryl rings in the cis conformation with methoxy groups on the aryl rings. The derivatives of CA-4 have been proved to have great inhibitor activity against tublin polymerization. Quinoline derivatives have great biological activities in many aspects, and our results have shown that quinazoline derivatives with anilino substituents on the 2-position exhibited good anticancer activity. A benzoyl group was introduced onto the 4-position of quinazoline to mimic CA-4. However, our results showed that even methoxy groups introduced onto the benzoyl moiety and 6,7-position of quinazoline could not achieve a good anticancer activity, it was reasoned that the two aromatic conformation. Therefore, derivatives of l-arylpyrrolo[3,2-c]quinoline were designed to force the two aromatic rings in cis conformations. The biological results showed that 3-OMe, 4-OMe, 3,4-OMe and 3-OH-4-OMe on the 1-phenyl group played an important role in l_aryl_4-methyl-2,3-dihydropyrrolo[3,2-c]quinoline derivatives. The aromatic planar structure is assumed essential to the inhibitory activity. We hope that the results presented here will promote further research on this series of compounds as potential anticancer therapeutic agents.
    關聯: 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會,起迄日:2011/04/06~2011/04/05,地點:溪頭台大實驗林
    显示于类别:[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

    文件中的档案:

    档案 描述 大小格式浏览次数
    pp-37.pdf89KbAdobe PDF435检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈