Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/24251
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 18074/20272 (89%)
造访人次 : 4091353      在线人数 : 5832
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.cnu.edu.tw/handle/310902800/24251


    標題: Synthesis of Designed Dextromethorphan Derivatives as Potential Neuroprotective Agents
    作者: Huey-Chwen Juang (莊惠淳)
    Wen-Hsin Huang (黃文鑫)
    Ann-Ron Lee (李安榮)
    日期: 2011
    上傳時間: 2011-06-23 14:57:36 (UTC+8)
    摘要: Research in neuroprotection is essential and eager for the development of therapies for neurodegenerative diseases such Alzheimer's disease and Parkinson's disease (PD) important on age-related diseases. Since the primary machinery for the production of neurotoxic factor and pro-inflammatory such as ROS, which cause dopamine (DA) neuron damage in microglia is NADPH oxidase (also called phagocyte oxidase, or PHOX), researches indicated that vital to the neuroprotective effect of DM acts on the NADPH oxidase activity. Dextromethorphan (DM) is originally a dextrorotary morphinan antitussive drug, which has been proven as a potential neuroprotective drug. 3-Hydroxymorphinan (3-HM) has shown the most potency for protect DA neurons among DM and DM's metabolite family, dextrophan (DX), 3-methoxymorphinan (3-MM), and 3-hydroxymorphinan (3-HM). Not only does 3-HM effectively inhibit microglia to reduce neurotoxicity, but also it stimulates astrocyte secretion neurotrophic factors to protect DA neurons. This newly discovered capacity to reduce microglial activation may pave a new path for potential use of DM-related compounds in treating neurodegenerative diseases. In search of neuroprotective agents the structural modification of DM was substantially conducted in our laboratories. Those target compounds are under pharmacological evaluations by in vitro suppressing the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-elicited microglia cells and for further a SAR study.
    關聯: 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
    显示于类别:[藥理學院] 2011年台俄有機、藥物與生物化學交流暨藥物化學研討會

    文件中的档案:

    档案 描述 大小格式浏览次数
    pp-35.pdf81KbAdobe PDF634检视/开启


    在CNU IR中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈