New Benzofuro[3,2-c]chromen-6-one from the Fruits of Psoralea corylifolia

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Title:	New Benzofuro[3,2-c]chromen-6-one from the Fruits of Psoralea corylifolia
Authors:	Yuan-Chih Chen (陳景祥) Rou-Wen Lai (賴柔雯) Hui-Chun Kang (康慧君) Hsin-Ling Wang (王馨翎) Jih-Jung Chen (陳日榮)
Date:	2011
Issue Date:	2011-06-23 14:57:33 (UTC+8)
Abstract:	Psoralea corylifolia (Chinese name Buguzhi), dry fruits of leguminous plant P. corylifolia L., is one of the most popular traditional Chinese medicines. This crude drug has used for the treatment of pollakiuria, enuresis, osteoporosis, depression, and various kidney problems. It is reported to contain coumarins, flavonoids, alkaloids, essential oil, and terpenoids. Many of these compounds were found to exhibit anti-allergic, antioxidant, antitumor, insecticidal, and antimicrobial activities. Investigation on w-hexane- and EtOAc-soluble fractions of the fruits of P. corylifolia has led to the isolation of a new benzofuro[3,2-c]chromen-6-one, psoracorylin A (1), together with eight known compounds, including angelicin (2), psoralen (3), bavachalcone (4), bakuchiol (5), 12,13-dihydro-12,13-epoxybakuchiol (6), /?-hydroxybenzaldehyde (7), (β-sitosterol (8), and stigmasterol (9). The structure of new compound 1 was determined through spectroscopic and MS analyses. This symposium describes the structural elucidation of 1 and the biological activities of the isolates.
Relation:	2011年台俄有機、藥物與生物化學交流暨藥物化學研討會，起迄日：2011/04/06~2011/04/05，地點：溪頭台大實驗林
Appears in Collections:	[Pharmacy and Science] 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions & PST Medicinal Chemistry Symposium

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